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Scopolamine impairs latent working m...

Jabitta, Sikirat Yewande.

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Scopolamine impairs latent working memory in the water maze.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Scopolamine impairs latent working memory in the water maze./
作者:	Jabitta, Sikirat Yewande.
面頁冊數:	67 p.
附註:	Source: Masters Abstracts International, Volume: 52-06.
Contained By:	Masters Abstracts International52-06(E).
標題:	Psychology, Behavioral Sciences. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1525320
ISBN:	9781303950049

Scopolamine impairs latent working memory in the water maze.
Jabitta, Sikirat Yewande.

Scopolamine impairs latent working memory in the water maze. - 67 p.

Source: Masters Abstracts International, Volume: 52-06.

Thesis (M.A.)--University of Houston-Clear Lake, 2014.

This Study evaluated latent learning in the water maze and the neurochemical mechanisms involved in this learning type. Most animal models of learning are based on trial-and-error learning: alterations of behavior by the success or failure of repeated attempts. However, humans can often acquire working memory helpful for performing a task without having to actually perform the task. Example: when you are new to the university, you see from a distance where the library is located. Later, when you need to check out a book, you walk straight into the library. This can be modeled in the Morris water maze (which is routinely used to explore neural mechanisms of working memory) through direct placement on the escape platform, followed by assessing the subject's performance in swimming back to the platform. The subjects were 18 Long-Evans hooded rats. All rats were pre-trained for three days in the escape procedure by swimming progressively longer distances back to the platform where they had been placed. During four days of working memory testing, 12 rats were injected with either saline or scopolamine and trained by direct placement on the platform in a different position each day. Six sham-trained rats were placed on a platform in a small cylinder in a different room. Five minutes later, all rats were placed in the fill-sized water maze and assessed for path length and latency to reach the escape platform. On two days, rats were injected intraperitoneally 30 minutes before training with 1 mg/kg scopolamine hydrobromide in saline, and on the other two they received saline alone. The order of drug and saline injections was counterbalanced among subjects. The results showed that trained rats tested without scopolamine were faster compared to all other conditions and had higher accuracy scores (shortest possible distance/total path length) to the platform compared with all other conditions. A probe trial (testing without a platform present) revealed that trained saline rats spent more time in the correct quadrant than any other groups, and traveled a longer path length in the correct quadrant. The overall results suggest that muscarinic cholinergie systems are essential to spatial learning by mere visual observation.

ISBN: 9781303950049Subjects--Topical Terms:

1669657
Psychology, Behavioral Sciences.

Scopolamine impairs latent working memory in the water maze.
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