東華大學圖書館 |

語系: 繁體中文

說明(常見問題)

回圖書館首頁

手機版館藏查詢

登入

回首頁

切換: 標籤 | MARC模式 | ISBD

A New Landmark-Independent Tool for ...

Rolfe, Sara.

FindBook

Google Book

Amazon

博客來

A New Landmark-Independent Tool for Quantifying and Characterizing Morphologic Variation.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	A New Landmark-Independent Tool for Quantifying and Characterizing Morphologic Variation./
作者:	Rolfe, Sara.
面頁冊數:	92 p.
附註:	Source: Dissertation Abstracts International, Volume: 75-12(E), Section: B.
Contained By:	Dissertation Abstracts International75-12B(E).
標題:	Engineering, Electronics and Electrical. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3631948
ISBN:	9781321111033

A New Landmark-Independent Tool for Quantifying and Characterizing Morphologic Variation.
Rolfe, Sara.

A New Landmark-Independent Tool for Quantifying and Characterizing Morphologic Variation. - 92 p.

Source: Dissertation Abstracts International, Volume: 75-12(E), Section: B.

Thesis (Ph.D.)--University of Washington, 2014.

As advances in multi-dimensional imaging are made, there is a growing need for tools that enable quantitative assessment of both embryonic and postnatal structure and form. To this end, this dissertation develops a landmark-independent, deformable-registration based framework for quantifying and characterizing morphologic variation. This framework can utilize 3D surface images generated by any multi-dimensional biomedical imaging modality and provides quantitative assessment of potentially biologically relevant changes in 3D shape whether natural, caused by mutation, or influenced by non-genetic factors. In this work, using different example datasets, the utility and sensitivity of the tools developed in this work are demonstrated: 1) to detect subtle morphological phenotypes in specimens; 2) to quantify morphologic change over a normal developmental time series of embryonic development; and 3) to determine the impact of transient localized genetic manipulation and environmental change on morphogenesis. The development of these tools will assist in defining trajectories of normal growth and help underpin hypotheses as to the developmental basis and the specific role of the causative gene in conditions causing disruptions to normal growth.

ISBN: 9781321111033Subjects--Topical Terms:

626636
Engineering, Electronics and Electrical.

A New Landmark-Independent Tool for Quantifying and Characterizing Morphologic Variation.
LDR:02145nam a2200277 4500 001 1967106
005 20141112075802.5
008 150210s2014 ||||||||||||||||| ||eng d
020 $a 9781321111033
035 $a (MiAaPQ)AAI3631948
035 $a AAI3631948
040 $a MiAaPQ $c MiAaPQ
100 1 $a Rolfe, Sara. $3 2104037
245 1 2 $a A New Landmark-Independent Tool for Quantifying and Characterizing Morphologic Variation.
300 $a 92 p.
500 $a Source: Dissertation Abstracts International, Volume: 75-12(E), Section: B.
500 $a Adviser: Linda G. Shapiro.
502 $a Thesis (Ph.D.)--University of Washington, 2014.
520 $a As advances in multi-dimensional imaging are made, there is a growing need for tools that enable quantitative assessment of both embryonic and postnatal structure and form. To this end, this dissertation develops a landmark-independent, deformable-registration based framework for quantifying and characterizing morphologic variation. This framework can utilize 3D surface images generated by any multi-dimensional biomedical imaging modality and provides quantitative assessment of potentially biologically relevant changes in 3D shape whether natural, caused by mutation, or influenced by non-genetic factors. In this work, using different example datasets, the utility and sensitivity of the tools developed in this work are demonstrated: 1) to detect subtle morphological phenotypes in specimens; 2) to quantify morphologic change over a normal developmental time series of embryonic development; and 3) to determine the impact of transient localized genetic manipulation and environmental change on morphogenesis. The development of these tools will assist in defining trajectories of normal growth and help underpin hypotheses as to the developmental basis and the specific role of the causative gene in conditions causing disruptions to normal growth.
590 $a School code: 0250.
650 4 $a Engineering, Electronics and Electrical. $3 626636
650 4 $a Health Sciences, Radiology. $3 1019076
690 $a 0544
690 $a 0574
710 2 $a University of Washington. $b Electrical Engineering. $3 2102369
773 0 $t Dissertation Abstracts International $g 75-12B(E).
790 $a 0250
791 $a Ph.D.
792 $a 2014
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3631948