語系:
繁體中文
English
說明(常見問題)
回圖書館首頁
手機版館藏查詢
登入
回首頁
切換:
標籤
|
MARC模式
|
ISBD
Modification of tumor micro-environm...
~
Wu, Chao-Yi Joy.
FindBook
Google Book
Amazon
博客來
Modification of tumor micro-environment to enhance anti-tumor immune response.
紀錄類型:
書目-語言資料,印刷品 : Monograph/item
正題名/作者:
Modification of tumor micro-environment to enhance anti-tumor immune response./
作者:
Wu, Chao-Yi Joy.
面頁冊數:
156 p.
附註:
Source: Dissertation Abstracts International, Volume: 74-12(E), Section: B.
Contained By:
Dissertation Abstracts International74-12B(E).
標題:
Health Sciences, Immunology. -
電子資源:
http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3573107
ISBN:
9781303422805
Modification of tumor micro-environment to enhance anti-tumor immune response.
Wu, Chao-Yi Joy.
Modification of tumor micro-environment to enhance anti-tumor immune response.
- 156 p.
Source: Dissertation Abstracts International, Volume: 74-12(E), Section: B.
Thesis (Ph.D.)--The Johns Hopkins University, 2013.
Increasing attention have been generated to minimized the adverse immune impact of tumor infiltrated myeloid cells to increase the anti-tumor immune response and potentially enhance tumor control. In present study, we've demonstrated that intratumorally administration of a peptide based vaccine in well defined solid tumor combining PADRE peptide and poly I:C leads to an enhanced antitumor effects in treated mice comparing with conventional vaccine route giving subcutaneous (Chapter 2). This challenges the prevailing notion of the tumor as an inherently immune-suppressive site and underscores the dynamic nature of interactions between the tumor and the immune system. Also, we evaluate the phenotype change of macrophages in the peritoneal cavity of disseminated ovarian cancer model after poly I:C treatment. With the help of PEI to increase the uptake of poly I:C by the peritoneal cells, significant improvement was observed in the antitumor effects against murine ovarian tumors. This anti-tumor effect was contributed by the alternative MI activation of peritoneal macrophages when treated and sequentially activate NK cells to clear tumor (Chapter 3). This suggests that the environment of ill-define disseminated tumors can also be changed to significantly benefit tumor control. Last, we focus on how conventional cancer treatments, tumor irradiation impact the tumor microenvironment. In chapter 4, we've show that by combining RT and targeted delivery of antigenic peptide to the tumor, the adjuvant effect generated by RT itself is sufficient to elicit the priming and expansion of antigen-specific CD8+ T cells through the type 1 interferon and toll like receptor 4 dependent pathways and leads to a potent therapeutic antitumor effect. In addition, we demonstrated that CTL-mediated killing of CD11b+ myeloid stromal cells, in the tumor by our approach is important for the control of tumor growth using two different transgenic mouse models. Altogether, we observed a greater tumor control achieved through the suppression of the immunomodulatory effects and the enhancement of favorable immune stimulation due to local RT. In summary, these results demonstrate that the immune-suppressive tumor micro-environment can be reversed by available, commonly practiced, interventions and provide impetus for the development and clinical translation of novel immune-based strategies for cancer therapy.
ISBN: 9781303422805Subjects--Topical Terms:
1017716
Health Sciences, Immunology.
Modification of tumor micro-environment to enhance anti-tumor immune response.
LDR
:03332nam a2200289 4500
001
1966815
005
20141112075114.5
008
150210s2013 ||||||||||||||||| ||eng d
020
$a
9781303422805
035
$a
(MiAaPQ)AAI3573107
035
$a
AAI3573107
040
$a
MiAaPQ
$c
MiAaPQ
100
1
$a
Wu, Chao-Yi Joy.
$3
2103695
245
1 0
$a
Modification of tumor micro-environment to enhance anti-tumor immune response.
300
$a
156 p.
500
$a
Source: Dissertation Abstracts International, Volume: 74-12(E), Section: B.
500
$a
Advisers: T.-C. Wu; Richard B. S. Roden.
502
$a
Thesis (Ph.D.)--The Johns Hopkins University, 2013.
520
$a
Increasing attention have been generated to minimized the adverse immune impact of tumor infiltrated myeloid cells to increase the anti-tumor immune response and potentially enhance tumor control. In present study, we've demonstrated that intratumorally administration of a peptide based vaccine in well defined solid tumor combining PADRE peptide and poly I:C leads to an enhanced antitumor effects in treated mice comparing with conventional vaccine route giving subcutaneous (Chapter 2). This challenges the prevailing notion of the tumor as an inherently immune-suppressive site and underscores the dynamic nature of interactions between the tumor and the immune system. Also, we evaluate the phenotype change of macrophages in the peritoneal cavity of disseminated ovarian cancer model after poly I:C treatment. With the help of PEI to increase the uptake of poly I:C by the peritoneal cells, significant improvement was observed in the antitumor effects against murine ovarian tumors. This anti-tumor effect was contributed by the alternative MI activation of peritoneal macrophages when treated and sequentially activate NK cells to clear tumor (Chapter 3). This suggests that the environment of ill-define disseminated tumors can also be changed to significantly benefit tumor control. Last, we focus on how conventional cancer treatments, tumor irradiation impact the tumor microenvironment. In chapter 4, we've show that by combining RT and targeted delivery of antigenic peptide to the tumor, the adjuvant effect generated by RT itself is sufficient to elicit the priming and expansion of antigen-specific CD8+ T cells through the type 1 interferon and toll like receptor 4 dependent pathways and leads to a potent therapeutic antitumor effect. In addition, we demonstrated that CTL-mediated killing of CD11b+ myeloid stromal cells, in the tumor by our approach is important for the control of tumor growth using two different transgenic mouse models. Altogether, we observed a greater tumor control achieved through the suppression of the immunomodulatory effects and the enhancement of favorable immune stimulation due to local RT. In summary, these results demonstrate that the immune-suppressive tumor micro-environment can be reversed by available, commonly practiced, interventions and provide impetus for the development and clinical translation of novel immune-based strategies for cancer therapy.
520
$a
iii.
590
$a
School code: 0098.
650
4
$a
Health Sciences, Immunology.
$3
1017716
650
4
$a
Health Sciences, Oncology.
$3
1018566
690
$a
0982
690
$a
0992
710
2
$a
The Johns Hopkins University.
$3
1017431
773
0
$t
Dissertation Abstracts International
$g
74-12B(E).
790
$a
0098
791
$a
Ph.D.
792
$a
2013
793
$a
English
856
4 0
$u
http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3573107
筆 0 讀者評論
館藏地:
全部
電子資源
出版年:
卷號:
館藏
1 筆 • 頁數 1 •
1
條碼號
典藏地名稱
館藏流通類別
資料類型
索書號
使用類型
借閱狀態
預約狀態
備註欄
附件
W9261821
電子資源
11.線上閱覽_V
電子書
EB
一般使用(Normal)
在架
0
1 筆 • 頁數 1 •
1
多媒體
評論
新增評論
分享你的心得
Export
取書館
處理中
...
變更密碼
登入