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Alterations in Hippocampal Functioni...

Mutso, Amelia Ashley.

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Alterations in Hippocampal Functioning in Chronic Pain.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Alterations in Hippocampal Functioning in Chronic Pain./
作者:	Mutso, Amelia Ashley.
面頁冊數:	159 p.
附註:	Source: Dissertation Abstracts International, Volume: 74-09(E), Section: B.
Contained By:	Dissertation Abstracts International74-09B(E).
標題:	Biology, Neuroscience. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3563799
ISBN:	9781303123009

Alterations in Hippocampal Functioning in Chronic Pain.
Mutso, Amelia Ashley.

Alterations in Hippocampal Functioning in Chronic Pain. - 159 p.

Source: Dissertation Abstracts International, Volume: 74-09(E), Section: B.

Thesis (Ph.D.)--Northwestern University, 2013.

Chronic pain is one of the largest medical health problems in the developed world. However, there continues to be a lack of efficacious treatments and patients continue to suffer both physically and emotionally. The understanding of chronic pain effects on the brain is essential for the development of successful treatments. We propose that chronic pain can be redefined as a state of continual learning coupled with an inability to extinguish aversive associations; therefore, the hippocampus, which is critically involved in learning and memory, may be significantly dysregulated in chronic pain. This thesis aims to identify unique hippocampal disruptions in chronic pain and how these changing properties may contribute to the persistence of pain. I will present three studies covering hippocampal changes in chronic pain in both animal models and human patients. Targeting the reversal of systematic changes could improve both patient quality of life and actual pain behavior.

ISBN: 9781303123009Subjects--Topical Terms:

1017680
Biology, Neuroscience.

Alterations in Hippocampal Functioning in Chronic Pain.
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500 $a Adviser: Apkar V. Apkarian.
502 $a Thesis (Ph.D.)--Northwestern University, 2013.
520 $a Chronic pain is one of the largest medical health problems in the developed world. However, there continues to be a lack of efficacious treatments and patients continue to suffer both physically and emotionally. The understanding of chronic pain effects on the brain is essential for the development of successful treatments. We propose that chronic pain can be redefined as a state of continual learning coupled with an inability to extinguish aversive associations; therefore, the hippocampus, which is critically involved in learning and memory, may be significantly dysregulated in chronic pain. This thesis aims to identify unique hippocampal disruptions in chronic pain and how these changing properties may contribute to the persistence of pain. I will present three studies covering hippocampal changes in chronic pain in both animal models and human patients. Targeting the reversal of systematic changes could improve both patient quality of life and actual pain behavior.
520 $a The initial study provides the first comprehensive investigation to elucidate the role of the hippocampus in chronic pain. We identify numerous hippocampal-dependent behavioral, molecular, and synaptic changes in an animal model of chronic pain, in addition to decreased hippocampal volume in chronic pain patients. Together these results demonstrate specific cellular correlates of observed cognitive and emotional problems seen in chronic pain, and provide the first evidence for clear hippocampal involvement in chronic pain.
520 $a The second study clarifies the role of hippocampal neurogenesis in the persistence of pain. We demonstrate that decreased hippocampal neurogenesis leads to decreased chronic pain behavior, and this change is reversible following the removal of neurogenesis inhibition. This indicates a mechanism which may underlie ongoing states of aversive learning in chronic pain.
520 $a The third study identifies how hippocampal functional connectivity is changing in patients during the transition to chronic pain. The findings indicate that hippocampal connectivity extent is distinct between patients and controls, and there are specific hippocampal functional network changes over time that differentiate sub-acute pain patients who recover from those who develop chronic pain. This suggests a significant role of the hippocampus in the transition to chronic pain and on learning and emotional deficits in patients.
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