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Nanoparticle mediated ablation of br...

Burford, Christopher.

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Nanoparticle mediated ablation of breast cancer cells using a nanosecond pulsed electric field.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Nanoparticle mediated ablation of breast cancer cells using a nanosecond pulsed electric field./
Author:	Burford, Christopher.
Description:	57 p.
Notes:	Source: Masters Abstracts International, Volume: 52-03.
Contained By:	Masters Abstracts International52-03(E).
Subject:	Engineering, Biomedical. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1524343
ISBN:	9781303549540

Nanoparticle mediated ablation of breast cancer cells using a nanosecond pulsed electric field.
Burford, Christopher.

Nanoparticle mediated ablation of breast cancer cells using a nanosecond pulsed electric field. - 57 p.

Source: Masters Abstracts International, Volume: 52-03.

Thesis (M.S.)--University of Missouri - Columbia, 2013.

In the past, both nanomaterials and various heating modalities have been researched as means for treating cancers. However, many of the current methodologies have the flaws of inconsistent tumor ablation and significant destruction of healthy cells. Based on research performed using constant radiofrequency electric fields and metallic nanoparticles (where cell necrosis is induced by the heating of these nanoparticles) we have developed a modality that simlarly uses functionalized metallic nanoparticles, specific for the T47D breast cancer cell line, and nanosecond pulsed electric fields as the hyperthermic inducer. Using both iron oxide and gold nanoparticles the results of our pilot studies indicated that up to 90% of the cancer cells were ablated given the optimal treatment parameters. These quantities of ablated cells were achieved using a cumulative exposure time 6 orders of magnitude less than most in vitro radiofrequency electric field studies.

ISBN: 9781303549540Subjects--Topical Terms:

1017684
Engineering, Biomedical.

Nanoparticle mediated ablation of breast cancer cells using a nanosecond pulsed electric field.
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008 150210s2013 ||||||||||||||||| ||eng d
020 $a 9781303549540
035 $a (MiAaPQ)AAI1524343
035 $a AAI1524343
040 $a MiAaPQ $c MiAaPQ
100 1 $a Burford, Christopher. $3 2102127
245 1 0 $a Nanoparticle mediated ablation of breast cancer cells using a nanosecond pulsed electric field.
300 $a 57 p.
500 $a Source: Masters Abstracts International, Volume: 52-03.
500 $a Adviser: John A. Viator.
502 $a Thesis (M.S.)--University of Missouri - Columbia, 2013.
520 $a In the past, both nanomaterials and various heating modalities have been researched as means for treating cancers. However, many of the current methodologies have the flaws of inconsistent tumor ablation and significant destruction of healthy cells. Based on research performed using constant radiofrequency electric fields and metallic nanoparticles (where cell necrosis is induced by the heating of these nanoparticles) we have developed a modality that simlarly uses functionalized metallic nanoparticles, specific for the T47D breast cancer cell line, and nanosecond pulsed electric fields as the hyperthermic inducer. Using both iron oxide and gold nanoparticles the results of our pilot studies indicated that up to 90% of the cancer cells were ablated given the optimal treatment parameters. These quantities of ablated cells were achieved using a cumulative exposure time 6 orders of magnitude less than most in vitro radiofrequency electric field studies.
590 $a School code: 0133.
650 4 $a Engineering, Biomedical. $3 1017684
650 4 $a Health Sciences, Oncology. $3 1018566
650 4 $a Nanotechnology. $3 526235
690 $a 0541
690 $a 0992
690 $a 0652
710 2 $a University of Missouri - Columbia. $b Biological Engineering. $3 2099840
773 0 $t Masters Abstracts International $g 52-03(E).
790 $a 0133
791 $a M.S.
792 $a 2013
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1524343