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A Synthetic-biology Approach to Unde...

Tanouchi, Yu.

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A Synthetic-biology Approach to Understanding Bacterial Programmed Death and Implications for Antibiotic Treatment.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	A Synthetic-biology Approach to Understanding Bacterial Programmed Death and Implications for Antibiotic Treatment./
作者:	Tanouchi, Yu.
面頁冊數:	178 p.
附註:	Source: Dissertation Abstracts International, Volume: 74-07(E), Section: B.
Contained By:	Dissertation Abstracts International74-07B(E).
標題:	Biology, Microbiology. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3556221
ISBN:	9781267980298

A Synthetic-biology Approach to Understanding Bacterial Programmed Death and Implications for Antibiotic Treatment.
Tanouchi, Yu.

A Synthetic-biology Approach to Understanding Bacterial Programmed Death and Implications for Antibiotic Treatment. - 178 p.

Source: Dissertation Abstracts International, Volume: 74-07(E), Section: B.

Thesis (Ph.D.)--Duke University, 2013.

Programmed death is often associated with a bacterial stress response. This behavior appears paradoxical, as it offers no benefit to the individual. This paradox can be explained if the death is altruistic': the sacrifice of some cells can benefit the survivors through release of public goods'. However, the conditions where bacterial programmed death becomes advantageous have not been unambiguously demonstrated experimentally. Here, I determined such conditions by engineering tunable, stress-induced altruistic death in the bacterium Escherichia coli. Using a mathematical model, we predicted the existence of an optimal programmed death rate that maximizes population growth under stress. I further predicted that altruistic death could generate the Eagle effect', a counter-intuitive phenomenon where bacteria appear to grow better when treated with higher antibiotic concentrations. In support of these modeling insights, I experimentally demonstrated both the optimality in programmed death rate and the Eagle effect using our engineered system. These findings fill a critical conceptual gap in the analysis of the evolution of bacterial programmed death, and have implications for a design of antibiotic treatment.

ISBN: 9781267980298Subjects--Topical Terms:

1017734
Biology, Microbiology.

A Synthetic-biology Approach to Understanding Bacterial Programmed Death and Implications for Antibiotic Treatment.
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520 $a Programmed death is often associated with a bacterial stress response. This behavior appears paradoxical, as it offers no benefit to the individual. This paradox can be explained if the death is altruistic': the sacrifice of some cells can benefit the survivors through release of public goods'. However, the conditions where bacterial programmed death becomes advantageous have not been unambiguously demonstrated experimentally. Here, I determined such conditions by engineering tunable, stress-induced altruistic death in the bacterium Escherichia coli. Using a mathematical model, we predicted the existence of an optimal programmed death rate that maximizes population growth under stress. I further predicted that altruistic death could generate the Eagle effect', a counter-intuitive phenomenon where bacteria appear to grow better when treated with higher antibiotic concentrations. In support of these modeling insights, I experimentally demonstrated both the optimality in programmed death rate and the Eagle effect using our engineered system. These findings fill a critical conceptual gap in the analysis of the evolution of bacterial programmed death, and have implications for a design of antibiotic treatment.
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