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Hydrogen NMR spectroscopic analysis ...

Wang, Sidney.

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Hydrogen NMR spectroscopic analysis of colon adenocarcinoma metabolites.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Hydrogen NMR spectroscopic analysis of colon adenocarcinoma metabolites./
作者:	Wang, Sidney.
面頁冊數:	105 p.
附註:	Source: Dissertation Abstracts International, Volume: 71-02, Section: B, page: 8720.
Contained By:	Dissertation Abstracts International71-02B.
標題:	Biophysics, General. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3396030
ISBN:	9781109644524

Hydrogen NMR spectroscopic analysis of colon adenocarcinoma metabolites.
Wang, Sidney.

Hydrogen NMR spectroscopic analysis of colon adenocarcinoma metabolites. - 105 p.

Source: Dissertation Abstracts International, Volume: 71-02, Section: B, page: 8720.

Thesis (Ph.D.)--Harvard University, 2010.

Paired samples of cancer and adjacent normal sections of colon tissue from colon adenocarcinoma patients were extracted by a methanol-chloroform-water mixture, partitioned into aqueous and organic phases, and subsequently examined by 1H NMR. Spectra were binned, normalized, and analyzed for significant statistical differences between normal and cancer groups. Principal component analysis and partial least squares discriminant analysis distinguished normal spectra from cancer with few false classifications for aqueous extractions, but were less successful in discriminating between normal and tumor tissues when applied to data acquired from organic extractions. Studies of organic spectra indicated that cholesterol, cholesterol esters, and phospholipids were elevated in cancer samples while triacylglycerol levels were depressed. Poly-unsaturated lipids also appeared predominantly in tumor biopsies, whereas mono-unsaturated lipids were more common in normal colon tissue. Analysis of aqueous samples showed increased quantities of uridine diphosphate N-acetyl-D-glucosamine, uracil, proline, lactate, O-phosphoethanolamine, glutamate, aspartate, oxidized glutathione, inosine monophosphate, and taurine in cancer spectra. In contrast, the metabolites glucose, myo-inositol, creatine, and scyllo-inositol were more prominent in normal spectra. The significant differences observed reflect normal and tumor cell metabolism in colon adenocarcinoma.

ISBN: 9781109644524Subjects--Topical Terms:

1019105
Biophysics, General.

Hydrogen NMR spectroscopic analysis of colon adenocarcinoma metabolites.
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500 $a Adviser: Julia Y. Wang.
502 $a Thesis (Ph.D.)--Harvard University, 2010.
520 $a Paired samples of cancer and adjacent normal sections of colon tissue from colon adenocarcinoma patients were extracted by a methanol-chloroform-water mixture, partitioned into aqueous and organic phases, and subsequently examined by 1H NMR. Spectra were binned, normalized, and analyzed for significant statistical differences between normal and cancer groups. Principal component analysis and partial least squares discriminant analysis distinguished normal spectra from cancer with few false classifications for aqueous extractions, but were less successful in discriminating between normal and tumor tissues when applied to data acquired from organic extractions. Studies of organic spectra indicated that cholesterol, cholesterol esters, and phospholipids were elevated in cancer samples while triacylglycerol levels were depressed. Poly-unsaturated lipids also appeared predominantly in tumor biopsies, whereas mono-unsaturated lipids were more common in normal colon tissue. Analysis of aqueous samples showed increased quantities of uridine diphosphate N-acetyl-D-glucosamine, uracil, proline, lactate, O-phosphoethanolamine, glutamate, aspartate, oxidized glutathione, inosine monophosphate, and taurine in cancer spectra. In contrast, the metabolites glucose, myo-inositol, creatine, and scyllo-inositol were more prominent in normal spectra. The significant differences observed reflect normal and tumor cell metabolism in colon adenocarcinoma.
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