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Dietary milk fat globule membrane re...

Snow, Dallin R.

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Dietary milk fat globule membrane reduces the incidence of aberrant crypt foci in Fischer-344 rats and provides protection against gastrointestinal stress in mice treated with lipopolysaccharide.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Dietary milk fat globule membrane reduces the incidence of aberrant crypt foci in Fischer-344 rats and provides protection against gastrointestinal stress in mice treated with lipopolysaccharide./
作者:	Snow, Dallin R.
面頁冊數:	99 p.
附註:	Source: Masters Abstracts International, Volume: 49-03, page: 1787.
Contained By:	Masters Abstracts International49-03.
標題:	Health Sciences, Nutrition. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1483794
ISBN:	9781124389493

Dietary milk fat globule membrane reduces the incidence of aberrant crypt foci in Fischer-344 rats and provides protection against gastrointestinal stress in mice treated with lipopolysaccharide.
Snow, Dallin R.

Dietary milk fat globule membrane reduces the incidence of aberrant crypt foci in Fischer-344 rats and provides protection against gastrointestinal stress in mice treated with lipopolysaccharide. - 99 p.

Source: Masters Abstracts International, Volume: 49-03, page: 1787.

Thesis (M.S.)--Utah State University, 2010.

Milk fat globule membrane surrounds the fat droplets of milk. It is a biopolymer containing primarily membrane glycoproteins and polar lipids which contribute to its properties as a possible neutraceutical. The aims of the studies were to determine if dietary milk fat globule membrane: (1) confers protection against colon carcinogenesis; and (2) promotes gut mucosal integrity while decreasing inflammation compared to diets containing corn oil or anhydrous milk fat.

ISBN: 9781124389493Subjects--Topical Terms:

1017801
Health Sciences, Nutrition.

Dietary milk fat globule membrane reduces the incidence of aberrant crypt foci in Fischer-344 rats and provides protection against gastrointestinal stress in mice treated with lipopolysaccharide.
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245 1 0 $a Dietary milk fat globule membrane reduces the incidence of aberrant crypt foci in Fischer-344 rats and provides protection against gastrointestinal stress in mice treated with lipopolysaccharide.
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500 $a Source: Masters Abstracts International, Volume: 49-03, page: 1787.
500 $a Adviser: Korry J. Hintze.
502 $a Thesis (M.S.)--Utah State University, 2010.
520 $a Milk fat globule membrane surrounds the fat droplets of milk. It is a biopolymer containing primarily membrane glycoproteins and polar lipids which contribute to its properties as a possible neutraceutical. The aims of the studies were to determine if dietary milk fat globule membrane: (1) confers protection against colon carcinogenesis; and (2) promotes gut mucosal integrity while decreasing inflammation compared to diets containing corn oil or anhydrous milk fat.
520 $a Aim 1. Three dietary treatments differing only in the fat source were formulated: (1) AIN-76A, corn oil; (2) AIN-76A, anhydrous milk fat; and (3) AIN-76A, 50% milk fat globule membrane, 50% anhydrous milk fat. Each diet was formulated to contain 50 g/kg diet of fat and to be identical in macro and micro nutrient content. To assess protection against colon carcinogenesis, male, weanling Fischer-344 rats were randomly assigned to one of the three dietary treatments. Animals were injected with 1,2-dimethylhydrazine once per week at weeks 3 and 4. After 13 weeks animals were sacrificed, colons were removed, and aberrant crypt foci were counted by microscopy.
520 $a Rats fed the milk fat globule membrane diet (n = 16) had significantly fewer aberrant crypt foci (20.9 +/- 5.7) compared to rats fed corn oil (n = 17) or anhydrous milk fat (n = 16) diets (31.3 +/- 9.5 and 29.8 +/- 11.4 respectively; P < 0.05).
520 $a Aim 2. Male BALB/c mice were randomly assigned to one of two diets: AIN-76A, corn oil or AIN-76A, 50% milk fat globule membrane, 50% anhydrous milk fat. After 5 weeks mice were injected with saline vehicle control or lipopolysaccharide and gavaged with dextran-FITC. To assess gut mucosal integrity and inflammation, serum samples were assayed for dextran-FITC 24 and 48 hours after gavage, and a panel of 16 cytokine concentrations was analyzed.
520 $a Serum concentrations of IL-6, IL-10, IL-17, MCP-1, IFNgamma, and TNFalpha decreased and gut permeability decreased 45% in lipopolysaccharide challenged mice fed milk fat globule membrane diet compared to control diet at 24 hours (P < 0.05).
520 $a Overall, the results of these aims suggest that diets containing milk fat globule membrane are protective against colon carcinogenesis, inhibit the inflammatory response, and protect against gastrointestinal stress.
590 $a School code: 0241.
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