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The regulation of PML phosphorylatio...

Chen, Jackie Wei-Chu.

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The regulation of PML phosphorylation and protein interaction in the DNA damage response pathway.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	The regulation of PML phosphorylation and protein interaction in the DNA damage response pathway./
作者:	Chen, Jackie Wei-Chu.
面頁冊數:	86 p.
附註:	Source: Masters Abstracts International, Volume: 48-06, page: 3635.
Contained By:	Masters Abstracts International48-06.
標題:	Health Sciences, Pathology. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=MR63611
ISBN:	9780494636114

The regulation of PML phosphorylation and protein interaction in the DNA damage response pathway.
Chen, Jackie Wei-Chu.

The regulation of PML phosphorylation and protein interaction in the DNA damage response pathway. - 86 p.

Source: Masters Abstracts International, Volume: 48-06, page: 3635.

Thesis (M.Sc.)--Dalhousie University (Canada), 2010.

The promyelocytic leukemia (PML) protein is a tumour suppressor that exists as multiple isoforms and plays a role in many cellular processes including apoptosis, cell senescence and DNA repair. DNA-PK and ATR are major DNA damage kinases that mediate the cell's response to DNA breaks. PML is a substrate of ATR, and DNA-PK can associate with PML isoform I. ATR and DNA-PK share overlapping substrates, and we now extend this list of substrates to include PML. In addition, I have analyzed the protein interactions of PML isoform IV, whose unique C-terminus can mediate interactions with other tumour suppressors including p53 and pRb. Using affinity purification techniques and mass spectrometry we have identified novel protein interactions with the C-terminus of PML IV that occur preferentially after DNA damage. These proteins include factors involved in apoptosis and provide new insights into the role played by PML in the DNA damage response.

ISBN: 9780494636114Subjects--Topical Terms:

1017854
Health Sciences, Pathology.

The regulation of PML phosphorylation and protein interaction in the DNA damage response pathway.
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