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Statistical Models and Algorithms fo...

Castellanos, Lucia.

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Statistical Models and Algorithms for Studying Hand and Finger Kinematics and their Neural Mechanisms.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Statistical Models and Algorithms for Studying Hand and Finger Kinematics and their Neural Mechanisms./
Author:	Castellanos, Lucia.
Description:	133 p.
Notes:	Source: Dissertation Abstracts International, Volume: 75-02(E), Section: B.
Contained By:	Dissertation Abstracts International75-02B(E).
Subject:	Computer Science. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3575211
ISBN:	9781303528743

Statistical Models and Algorithms for Studying Hand and Finger Kinematics and their Neural Mechanisms.
Castellanos, Lucia.

Statistical Models and Algorithms for Studying Hand and Finger Kinematics and their Neural Mechanisms. - 133 p.

Source: Dissertation Abstracts International, Volume: 75-02(E), Section: B.

Thesis (Ph.D.)--Carnegie Mellon University, 2013.

The primate hand, a biomechanical structure with over twenty kinematic degrees of freedom, has an elaborate anatomical architecture. Although the hand requires complex, coordinated neural control, it endows its owner with an astonishing range of dexterous finger movements. Despite a century of research, however, the neural mechanisms that enable finger and grasping movements in primates are largely unknown. In this thesis, we investigate statistical models of finger movement that can provide insights into the mechanics of the hand, and that can have applications in neural-motor prostheses, enabling people with limb loss to regain natural function of the hands.

ISBN: 9781303528743Subjects--Topical Terms:

626642
Computer Science.

Statistical Models and Algorithms for Studying Hand and Finger Kinematics and their Neural Mechanisms.
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020 $a 9781303528743
035 $a (MiAaPQ)AAI3575211
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040 $a MiAaPQ $c MiAaPQ
100 1 $a Castellanos, Lucia. $3 2096242
245 1 0 $a Statistical Models and Algorithms for Studying Hand and Finger Kinematics and their Neural Mechanisms.
300 $a 133 p.
500 $a Source: Dissertation Abstracts International, Volume: 75-02(E), Section: B.
500 $a Adviser: Robert E. Kass.
502 $a Thesis (Ph.D.)--Carnegie Mellon University, 2013.
520 $a The primate hand, a biomechanical structure with over twenty kinematic degrees of freedom, has an elaborate anatomical architecture. Although the hand requires complex, coordinated neural control, it endows its owner with an astonishing range of dexterous finger movements. Despite a century of research, however, the neural mechanisms that enable finger and grasping movements in primates are largely unknown. In this thesis, we investigate statistical models of finger movement that can provide insights into the mechanics of the hand, and that can have applications in neural-motor prostheses, enabling people with limb loss to regain natural function of the hands.
520 $a There are many challenges associated with (1) the understanding and modeling of the kinematics of fingers, and (2) the mapping of intracortical neural recordings into motor commands that can be used to control a Brain-Machine Interface. These challenges include: potential nonlinearities; confounded sources of variation in experimental datasets; and dealing with high degrees of kinematic freedom.
520 $a In this work we analyze kinematic and neural datasets from repeated-trial experiments of hand motion, with the following contributions:
520 $a We identified static, nonlinear, low-dimensional representations of grasping finger motion, with accompanying evidence that these nonlinear representations are better than linear representations at predicting the type of object being grasped over the course of a reach-to-grasp movement. In addition, we show evidence of better encoding of these nonlinear (versus linear) representations in the firing of some neurons collected from the primary motor cortex of rhesus monkeys.
520 $a A functional alignment of grasping trajectories, based on total kinetic energy, as a strategy to account for temporal variation and to exploit a repeated-trial experiment structure.
520 $a An interpretable model for extracting dynamic synergies of finger motion, based on Gaussian Processes, that decomposes and reduces the dimensionality of variance in the dataset. We derive efficient algorithms for parameter estimation, show accurate reconstruction of grasping trajectories, and illustrate the interpretation of the model parameters.
520 $a Sound evidence of single-neuron decoding of interpretable grasping events, plus insights about the amount of grasping information extractable from just a single neuron.
520 $a The Laplace Gaussian Filter (LGF), a deterministic approximation to the posterior mean that is more accurate than Monte Carlo approximations for the same computational cost, and that in an off-line decoding task is more accurate than the standard Population Vector Algorithm.
590 $a School code: 0041.
650 4 $a Computer Science. $3 626642
650 4 $a Biology, Neuroscience. $3 1017680
650 4 $a Biophysics, Biomechanics. $3 1035342
690 $a 0984
690 $a 0317
690 $a 0648
710 2 $a Carnegie Mellon University. $b Machine Learning. $3 2094142
773 0 $t Dissertation Abstracts International $g 75-02B(E).
790 $a 0041
791 $a Ph.D.
792 $a 2013
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3575211