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Broad-spectrum antibacterial propert...

Ottomeyer, Megan.

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Broad-spectrum antibacterial properties of metal-ion doped borate bioactive glasses for clinical applications.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Broad-spectrum antibacterial properties of metal-ion doped borate bioactive glasses for clinical applications./
作者:	Ottomeyer, Megan.
面頁冊數:	56 p.
附註:	Source: Masters Abstracts International, Volume: 52-02.
Contained By:	Masters Abstracts International52-02(E).
標題:	Biology, Microbiology. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1523724
ISBN:	9781303352430

Broad-spectrum antibacterial properties of metal-ion doped borate bioactive glasses for clinical applications.
Ottomeyer, Megan.

Broad-spectrum antibacterial properties of metal-ion doped borate bioactive glasses for clinical applications. - 56 p.

Source: Masters Abstracts International, Volume: 52-02.

Thesis (M.S.)--Missouri University of Science and Technology, 2013.

Bioactive glasses with antimicrobial properties can be implemented as coatings on medical devices and implants, as well as a treatment for tissue repair and prevention of common hospital-acquired infections such as MRSA. A borate-containing glass, B3, is also undergoing clinical trials to assess wound-healing properties. The sensitivities of various bacteria to B3, B3-Ag, B3-Ga, and B3-I bioactive glasses were tested. In addition, the mechanism of action for the glasses was studied by spectroscopic enzyme kinetics experiments, Live-Dead staining fluorescence microscopy, and luminescence assays using two gene fusion strains of Escherichia coli.

ISBN: 9781303352430Subjects--Topical Terms:

1017734
Biology, Microbiology.

Broad-spectrum antibacterial properties of metal-ion doped borate bioactive glasses for clinical applications.
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500 $a Adviser: David Westenberg.
502 $a Thesis (M.S.)--Missouri University of Science and Technology, 2013.
520 $a Bioactive glasses with antimicrobial properties can be implemented as coatings on medical devices and implants, as well as a treatment for tissue repair and prevention of common hospital-acquired infections such as MRSA. A borate-containing glass, B3, is also undergoing clinical trials to assess wound-healing properties. The sensitivities of various bacteria to B3, B3-Ag, B3-Ga, and B3-I bioactive glasses were tested. In addition, the mechanism of action for the glasses was studied by spectroscopic enzyme kinetics experiments, Live-Dead staining fluorescence microscopy, and luminescence assays using two gene fusion strains of Escherichia coli.
520 $a It was found that gram-positive bacteria were more sensitive to all four glasses than gram negative bacteria, and that a single mechanism of action for the glasses is unlikely, as the rates of catalysis for metabolic enzymes as well as membrane permeability were altered after glass exposure.
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