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Part A: Palladium-Catalyzed Carbon-H...

Lapointe, David.

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Part A: Palladium-Catalyzed Carbon-Hydrogen Bond Functionalization Part B: Studies Toward the Synthesis of Ginkgolide C using Gold(I) Catalysis.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Part A: Palladium-Catalyzed Carbon-Hydrogen Bond Functionalization Part B: Studies Toward the Synthesis of Ginkgolide C using Gold(I) Catalysis./
Author:	Lapointe, David.
Description:	314 p.
Notes:	Source: Dissertation Abstracts International, Volume: 74-09(E), Section: B.
Contained By:	Dissertation Abstracts International74-09B(E).
Subject:	Chemistry, Inorganic. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=NR98027
ISBN:	9780494980279

Part A: Palladium-Catalyzed Carbon-Hydrogen Bond Functionalization Part B: Studies Toward the Synthesis of Ginkgolide C using Gold(I) Catalysis.
Lapointe, David.

Part A: Palladium-Catalyzed Carbon-Hydrogen Bond Functionalization Part B: Studies Toward the Synthesis of Ginkgolide C using Gold(I) Catalysis. - 314 p.

Source: Dissertation Abstracts International, Volume: 74-09(E), Section: B.

Thesis (Ph.D.)--University of Ottawa (Canada), 2012.

The field of metal-catalyzed C--H bond functionalizations is an incredibly vibrant and spans beyond the formations of biaryl motifs. The introduction chapter will cover the mechanistic aspects of the C--H bond functionalization with metal-carboxylate complexes. The mechanistic facets of this reaction will be the main conducting line between the different sections and chapters of the first part of this thesis. In the second chapter, will be described additives that can readily promoted C--H bond arylation of poorly reactive substrates. More specifically, we will revisit the intramolecular direct arylation reaction we will demonstrate the effect of pivalic acid as a co-catalyst by developing milder reaction conditions. In the third chapter we be described experimental and computational studies which suggested that the a single pathway might be involved in the palladium-catalyzed C--H bond functionalization of a wide range of (hetero)arene. Following this we will describe a general set of conditions for the direct arylation of wide range of heteroarenes. Also, we will present two different strategies to selectively and predictably arylate substrates containing multiple functionalizable C--H bonds. In the fourth chapter will be presented our efforts toward the development of new C--H bond functionalization methods in which we could apply our knowledge on the C--H bond cleavage and apply it to the formation of new scaffolds. The development of two new palladium-catalyzed methods were also described. In the fifth chapter, our effort toward the development of ligands to specifically promoted C--H bond cleavage will be presented. In the sixth chapter will be presented the latest results on the study of the mechanism of the C--H bond cleavage combining experimental and computational studies. In part B of this thesis will be presented our strategy toward the total synthesis of ginkgolide C that included two gold(I)-catalyzed reactions as key steps in the preparation of the spiro[4.4]nonane core of this natural product. The first studies on the feasibility of the key steps of the synthesis will be described.

ISBN: 9780494980279Subjects--Topical Terms:

517253
Chemistry, Inorganic.

Part A: Palladium-Catalyzed Carbon-Hydrogen Bond Functionalization Part B: Studies Toward the Synthesis of Ginkgolide C using Gold(I) Catalysis.
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245 1 0 $a Part A: Palladium-Catalyzed Carbon-Hydrogen Bond Functionalization Part B: Studies Toward the Synthesis of Ginkgolide C using Gold(I) Catalysis.
300 $a 314 p.
500 $a Source: Dissertation Abstracts International, Volume: 74-09(E), Section: B.
500 $a Advisers: Keith Fagnou; Louis Barriault.
502 $a Thesis (Ph.D.)--University of Ottawa (Canada), 2012.
520 $a The field of metal-catalyzed C--H bond functionalizations is an incredibly vibrant and spans beyond the formations of biaryl motifs. The introduction chapter will cover the mechanistic aspects of the C--H bond functionalization with metal-carboxylate complexes. The mechanistic facets of this reaction will be the main conducting line between the different sections and chapters of the first part of this thesis. In the second chapter, will be described additives that can readily promoted C--H bond arylation of poorly reactive substrates. More specifically, we will revisit the intramolecular direct arylation reaction we will demonstrate the effect of pivalic acid as a co-catalyst by developing milder reaction conditions. In the third chapter we be described experimental and computational studies which suggested that the a single pathway might be involved in the palladium-catalyzed C--H bond functionalization of a wide range of (hetero)arene. Following this we will describe a general set of conditions for the direct arylation of wide range of heteroarenes. Also, we will present two different strategies to selectively and predictably arylate substrates containing multiple functionalizable C--H bonds. In the fourth chapter will be presented our efforts toward the development of new C--H bond functionalization methods in which we could apply our knowledge on the C--H bond cleavage and apply it to the formation of new scaffolds. The development of two new palladium-catalyzed methods were also described. In the fifth chapter, our effort toward the development of ligands to specifically promoted C--H bond cleavage will be presented. In the sixth chapter will be presented the latest results on the study of the mechanism of the C--H bond cleavage combining experimental and computational studies. In part B of this thesis will be presented our strategy toward the total synthesis of ginkgolide C that included two gold(I)-catalyzed reactions as key steps in the preparation of the spiro[4.4]nonane core of this natural product. The first studies on the feasibility of the key steps of the synthesis will be described.
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