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Effect Modification by Influenza on ...

Gluskin, Rebecca Tave.

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Effect Modification by Influenza on the Short-term Relationship between Fine Particles, Temperature and Cardiovascular Mortality.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Effect Modification by Influenza on the Short-term Relationship between Fine Particles, Temperature and Cardiovascular Mortality./
Author:	Gluskin, Rebecca Tave.
Description:	129 p.
Notes:	Source: Dissertation Abstracts International, Volume: 74-01(E), Section: B.
Contained By:	Dissertation Abstracts International74-01B(E).
Subject:	Health Sciences, Epidemiology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3524154
ISBN:	9781267583840

Effect Modification by Influenza on the Short-term Relationship between Fine Particles, Temperature and Cardiovascular Mortality.
Gluskin, Rebecca Tave.

Effect Modification by Influenza on the Short-term Relationship between Fine Particles, Temperature and Cardiovascular Mortality. - 129 p.

Source: Dissertation Abstracts International, Volume: 74-01(E), Section: B.

Thesis (Ph.D.)--New York University, 2012.

Background: Exposure to cold temperature, air pollution and influenza are important determinants of cardiovascular disease (CVD) mortality; however, it is unclear whether these exposures interact in determining the risk of death from CVD. The objective of this study is to understand the role of influenza-like illness (ILI) as a modifier of the relationship between cold temperatures, air pollution particulate matter 2.5 (PM2.5) and daily CVD mortality.

ISBN: 9781267583840Subjects--Topical Terms:

1019544
Health Sciences, Epidemiology.

Effect Modification by Influenza on the Short-term Relationship between Fine Particles, Temperature and Cardiovascular Mortality.
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020 $a 9781267583840
035 $a (MiAaPQ)AAI3524154
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100 1 $a Gluskin, Rebecca Tave. $3 2093223
245 1 0 $a Effect Modification by Influenza on the Short-term Relationship between Fine Particles, Temperature and Cardiovascular Mortality.
300 $a 129 p.
500 $a Source: Dissertation Abstracts International, Volume: 74-01(E), Section: B.
500 $a Advisers: Kazuhiko Ito; George Thurston.
502 $a Thesis (Ph.D.)--New York University, 2012.
520 $a Background: Exposure to cold temperature, air pollution and influenza are important determinants of cardiovascular disease (CVD) mortality; however, it is unclear whether these exposures interact in determining the risk of death from CVD. The objective of this study is to understand the role of influenza-like illness (ILI) as a modifier of the relationship between cold temperatures, air pollution particulate matter 2.5 (PM2.5) and daily CVD mortality.
520 $a Methods: In this study, we estimated influenza-like illness incidence from Google Flu Trends (GFT) after validating use by comparison to ILI data was first validated with other available ILI datasets. I considered ILI, temperature, and PM2.5 in relation to daily CVD mortality counts in 67 United States metropolitan areas, from the fall of 2003 through 2006. In the first stage, I used Poisson time-series regression modeling to estimate the effects of temperature, at its lowest quintile in each city and each year during the cold season (October -- March), at lag 0 through 3 days and by distributed lag, while adjusting for temporal trends and day of week. I found that the cold season PM2.5 analysis did not have enough statistical power to investigate effect modification. In a second-stage mixed-effects model, we included the annual ILI mean intensity estimates from GFT database for each city and each winter. To measure other potential city level modifiers of CVD risk, I included average temperature, population density, the percent over age 65, percent poverty, latitude and PM2.5.
520 $a Results: In the main analysis, of the effect lags considered, the 2-day lagged coldest quintile of temperature showed the strongest significant association with increased CVD mortality, with an excess risk of 3.9% (95% confidence interval: 2.92, 5.00%). Winter influenza intensity modified the effect of temperature on CVD mortality; an increase in ILI of one inter-quartile range resulted in an increase of 31% in the temperature CVD mortality risk by 31% (95% confidence interval 5.07, 56.22%). No significant effects were seen in the other potential effect modifiers.
520 $a Conclusions: My research suggests that influenza-like illness (ILI) severity modifies the effects of cold temperature on cardiovascular disease (CVD) mortality. An understanding of factors that modify temperature related health effects is increasingly important in the face of climate change.
590 $a School code: 0146.
650 4 $a Health Sciences, Epidemiology. $3 1019544
650 4 $a Environmental Health. $3 578282
650 4 $a Statistics. $3 517247
690 $a 0766
690 $a 0470
690 $a 0463
710 2 $a New York University. $b Environmental Health Medicine. $3 2093224
773 0 $t Dissertation Abstracts International $g 74-01B(E).
790 $a 0146
791 $a Ph.D.
792 $a 2012
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3524154