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Language outcome after left temporal...

Janecek, Julie K.

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Language outcome after left temporal lobectomy in patients with discordant fMRI and sodium amobarbital testing results.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Language outcome after left temporal lobectomy in patients with discordant fMRI and sodium amobarbital testing results./
作者:	Janecek, Julie K.
面頁冊數:	169 p.
附註:	Source: Dissertation Abstracts International, Volume: 72-02, Section: B, page: 1187.
Contained By:	Dissertation Abstracts International72-02B.
標題:	Psychology, Psychobiology. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3433939
ISBN:	9781124401614

Language outcome after left temporal lobectomy in patients with discordant fMRI and sodium amobarbital testing results.
Janecek, Julie K.

Language outcome after left temporal lobectomy in patients with discordant fMRI and sodium amobarbital testing results. - 169 p.

Source: Dissertation Abstracts International, Volume: 72-02, Section: B, page: 1187.

Thesis (Ph.D.)--Marquette University, 2011.

The rationale for this study was to examine (1) language lateralization discordance rates between fMRI and the IAT in pre-surgical epilepsy patients and (2) naming outcome after left ATL in a group of patients for whom IAT and fMRI language LIs were discordant. Participants were 229 consecutive pre-surgical epilepsy patients who underwent the IAT and fMRI. IAT LIs (% correct inject right –% correct inject left condition) were calculated based on performance on comprehension, naming, repetition and reading language tasks. The fMRI LIs [(L-R)/(L+R) where L = number of activated left hemisphere voxels and R = number of activated right hemisphere voxels) were calculated for lateral, angular gyrus, temporal, and frontal regions of interest (ROIs) using a published semantic decision task. Discordance was determined using cut scores and difference scores for each method. Regression analyses were performed to investigate predictors of discordance. Additionally, regression formulas developed from a separate sample for predicting language outcome using fMRI and IAT LIs were applied to the discordant cases so that observed and predicted outcome scores could be compared with each method. Discordance rates ranged from 14–17%, depending on ROI. Atypical language dominance on fMRI was most predictive of discordance. Of discordant cases who underwent left ATL, language outcome was more accurately predicted by each method in approximately half the cases. When fMRI indicates left language dominance, IAT LI concordance is high. However, when fMRI indicates atypical language dominance, concordance rates with the IAT decrease. Post-operative language outcome data suggests that the IAT and fMRI each predict outcome in certain cases, suggesting some error variance with each mapping method.

ISBN: 9781124401614Subjects--Topical Terms:

1017821
Psychology, Psychobiology.

Language outcome after left temporal lobectomy in patients with discordant fMRI and sodium amobarbital testing results.
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500 $a Advisers: Alan W. Burkard; Sara J. Swanson.
502 $a Thesis (Ph.D.)--Marquette University, 2011.
520 $a The rationale for this study was to examine (1) language lateralization discordance rates between fMRI and the IAT in pre-surgical epilepsy patients and (2) naming outcome after left ATL in a group of patients for whom IAT and fMRI language LIs were discordant. Participants were 229 consecutive pre-surgical epilepsy patients who underwent the IAT and fMRI. IAT LIs (% correct inject right –% correct inject left condition) were calculated based on performance on comprehension, naming, repetition and reading language tasks. The fMRI LIs [(L-R)/(L+R) where L = number of activated left hemisphere voxels and R = number of activated right hemisphere voxels) were calculated for lateral, angular gyrus, temporal, and frontal regions of interest (ROIs) using a published semantic decision task. Discordance was determined using cut scores and difference scores for each method. Regression analyses were performed to investigate predictors of discordance. Additionally, regression formulas developed from a separate sample for predicting language outcome using fMRI and IAT LIs were applied to the discordant cases so that observed and predicted outcome scores could be compared with each method. Discordance rates ranged from 14–17%, depending on ROI. Atypical language dominance on fMRI was most predictive of discordance. Of discordant cases who underwent left ATL, language outcome was more accurately predicted by each method in approximately half the cases. When fMRI indicates left language dominance, IAT LI concordance is high. However, when fMRI indicates atypical language dominance, concordance rates with the IAT decrease. Post-operative language outcome data suggests that the IAT and fMRI each predict outcome in certain cases, suggesting some error variance with each mapping method.
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