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Stimulation of intake and preference...

Zukerman, Steven.

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Stimulation of intake and preference conditioning by postoral actions of sugars in sweet ageusic and normal mice: role of gut sugar sensors.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Stimulation of intake and preference conditioning by postoral actions of sugars in sweet ageusic and normal mice: role of gut sugar sensors./
作者:	Zukerman, Steven.
面頁冊數:	120 p.
附註:	Source: Dissertation Abstracts International, Volume: 74-07(E), Section: B.
Contained By:	Dissertation Abstracts International74-07B(E).
標題:	Psychology, Psychobiology. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3557124
ISBN:	9781267998811

Stimulation of intake and preference conditioning by postoral actions of sugars in sweet ageusic and normal mice: role of gut sugar sensors.
Zukerman, Steven.

Stimulation of intake and preference conditioning by postoral actions of sugars in sweet ageusic and normal mice: role of gut sugar sensors. - 120 p.

Source: Dissertation Abstracts International, Volume: 74-07(E), Section: B.

Thesis (Ph.D.)--City University of New York, 2013.

The sweet taste of natural sugars and artificial sweeteners is mediated by the T1r2+T1r3 sweet receptor and Trpm5 taste signaling protein. Experiment 1 examined the response of sweet ageusic T1r3 or Trpm5 knockout (KO) mice and C57BL/6 wild type (WT) mice to 0.5-32% solutions of glucose, fructose or galactose in 24-h two-bottle tests vs. water. The WT preferred glucose and fructose at 2-32%, and galactose at 4-16%. The T1r3 KO mice preferred glucose and galactose at 8-32% and 8%, respectively, and the Trpm5 KO preferred glucose and galactose at 16-32% and 8%, respectively. The two KO groups were indifferent to 0.5-8% fructose and avoided the sugar at 16-32%; all three groups avoided 32% galactose. The source of fructose avoidance remains unclear, although galactose avoidance appears related to impaired metabolism. The glucose and galactose preferences of the KO mice are attributed to the postoral conditioning actions of the sugars.

ISBN: 9781267998811Subjects--Topical Terms:

1017821
Psychology, Psychobiology.

Stimulation of intake and preference conditioning by postoral actions of sugars in sweet ageusic and normal mice: role of gut sugar sensors.
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245 1 0 $a Stimulation of intake and preference conditioning by postoral actions of sugars in sweet ageusic and normal mice: role of gut sugar sensors.
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500 $a Source: Dissertation Abstracts International, Volume: 74-07(E), Section: B.
500 $a Adviser: Anthony Sclafani.
502 $a Thesis (Ph.D.)--City University of New York, 2013.
520 $a The sweet taste of natural sugars and artificial sweeteners is mediated by the T1r2+T1r3 sweet receptor and Trpm5 taste signaling protein. Experiment 1 examined the response of sweet ageusic T1r3 or Trpm5 knockout (KO) mice and C57BL/6 wild type (WT) mice to 0.5-32% solutions of glucose, fructose or galactose in 24-h two-bottle tests vs. water. The WT preferred glucose and fructose at 2-32%, and galactose at 4-16%. The T1r3 KO mice preferred glucose and galactose at 8-32% and 8%, respectively, and the Trpm5 KO preferred glucose and galactose at 16-32% and 8%, respectively. The two KO groups were indifferent to 0.5-8% fructose and avoided the sugar at 16-32%; all three groups avoided 32% galactose. The source of fructose avoidance remains unclear, although galactose avoidance appears related to impaired metabolism. The glucose and galactose preferences of the KO mice are attributed to the postoral conditioning actions of the sugars.
520 $a Experiments 2-4 investigated postoral sugar conditioning in WT mice. They were trained (1 h/day) to drink flavored saccharin solutions with one flavor (CS+) paired with intragastric (IG) self-infusions of sugar or glucose analogs, and a second flavor (CS-) paired with IG water infusions. The mice increased their CS+ intake when infused with 4, 8, or 16% glucose, and showed a preference for the CS+ paired with IG 8%, 16%, or 32% glucose. Mice that infused 8% glucose intraperitoneally did not condition a CS+ preference. IG infusions of 8% or 12% galactose, 3-O-methylglucose (OMG) or methyl-&agr;-D-glucopyranoside (MDG), which bind to the SGLT1 glucose/galactose transporter and/or SGLT3 glucose sensor, increased CS+ intake whereas fructose infusions were ineffective. Galactose and MDG, but not OMG or fructose infusions also conditioned a CS+ preference. Phloridzin, a competitive inhibitor of SGLT1 and SGLT3, blocked intake stimulation and flavor conditioning by MDG but not by glucose. These findings suggest that activation of gut SGLT1 and/or SGLT3 sensors mediate, in part, the appetite stimulating actions of nutritive sugars and non-nutritive glucose analogs although other pre- and/or postabsorptive sensors may contribute as well to this process.
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790 1 0 $a Ackroff, Karen $e committee member
790 1 0 $a Delamater, Andrew R. $e committee member
790 1 0 $a Glendinning, John I. $e committee member
790 1 0 $a Bodnar, Richard J. $e committee member
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