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The Effects of Benzyl Alcohol on the...

Schnapp, Alaina M.

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The Effects of Benzyl Alcohol on the Developing Zebrafish (Danio rerio).

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	The Effects of Benzyl Alcohol on the Developing Zebrafish (Danio rerio)./
作者:	Schnapp, Alaina M.
面頁冊數:	46 p.
附註:	Source: Masters Abstracts International, Volume: 51-06.
Contained By:	Masters Abstracts International51-06(E).
標題:	Health Sciences, Toxicology. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1537833
ISBN:	9781303097751

The Effects of Benzyl Alcohol on the Developing Zebrafish (Danio rerio).
Schnapp, Alaina M.

The Effects of Benzyl Alcohol on the Developing Zebrafish (Danio rerio). - 46 p.

Source: Masters Abstracts International, Volume: 51-06.

Thesis (M.S.P.S.)--The University of Toledo, 2013.

Benzyl alcohol (C6H5CH2OH) is a preservative used in IV preparations, cosmetics, hair dyes, perfumes, and soaps. It is also used as a solvent for many organic processes and in industrial applications. It is an organic compound whose polarity and low vapor pressure make it a useful industrial solvent. We designed a series of experiments to study the developmental effects of benzyl alcohol exposure on zebrafish (Danio rerio), a well-established model for development. Zebrafish were exposed starting at high blastula stage of development (4 hours post-fertilization, hpf) and finishing at free swimming larvae stage (144 hpf). Observations of critical developmental endpoints were conducted at 8 hpf, 24 hpf, 32 hpf, 55 hpf, 80 hpf, and 144 hpf. The exposure of zebrafish embryos to varying concentrations of benzyl alcohol at 4 hpf in development resulted in developmental defects including delayed and/or abnormal eye development, cardiac/yolk sac edema, and cardiovascular abnormalities. The chemical's effects on neuronal outgrowth as a measured by acetylated alpha-tubulin staining were inconclusive for the concentrations studied.Cell death was observed using an acridine orange assay, showing a dramatic increase in cell death in a dose-dependent manner. While more work is needed to elucidate the effects of benzyl alcohol, these preliminary data suggest that there is a strong link between exposure to benzyl alcohol and the developmental defects observed.

ISBN: 9781303097751Subjects--Topical Terms:

1017752
Health Sciences, Toxicology.

The Effects of Benzyl Alcohol on the Developing Zebrafish (Danio rerio).
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