Absorption and drug development = so...
Avdeef, Alex.

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  • Absorption and drug development = solubility, permeability, and charge state /
  • 紀錄類型: 書目-電子資源 : Monograph/item
    正題名/作者: Absorption and drug development/ Alex Avdeef.
    其他題名: solubility, permeability, and charge state /
    作者: Avdeef, Alex.
    出版者: Hoboken, N.J. :Wiley-Interscience, : c2003.,
    面頁冊數: 1 online resource (xxiv, 287 p.) :ill.
    附註: Wiley online library (ebook collection)
    內容註: Cover -- CONTENTS -- PREFACE -- ACKNOWLEDGMENTS -- DEFINITIONS -- 1 INTRODUCTION -- 1.1 Shotgun Searching for Drugs? -- 1.2 Screen for the Target or ADME First? -- 1.3 ADME and Multimechanism Screens -- 1.4 ADME and Medicinal Chemists -- 1.5 The "A" in ADME -- 1.6 It is Not Just a Number"It is a Multimechanism -- 2 TRANSPORT MODEL -- 2.1 Permeability-Solubility-Charge State and the pH Partition Hypothesis -- 2.2 Properties of the Gastrointestinal Tract (GIT) -- 2.3 pH Microclimate -- 2.4 Intracellular pH Environment -- 2.5 Tight-Junction Complex -- 2.6 Structure of Octanol -- 2.7 Biopharmaceutics Classification System -- 3 CHARGE STATE -- 3.1 Constant Ionic Medium Reference State -- 3.2 pK(a) Databases -- 3.3 Potentiometric Measurements -- 3.3.1 Bjerrum Plots -- 3.3.2 pH Definitions and Electrode Standardization -- 3.3.3 The Solubility Problem'' and Cosolvent Methods -- 3.3.4 Use of Cosolvents for Water-Soluble Molecules -- 3.4 Spectrophotometric Measurements -- 3.5 Capillary Electrophoresis Measurements -- 3.6 Chromatographic pK(a) Measurement -- 3.7 pK(a) Microconstants -- 3.8 pK(a) "Gold Standard" for Drug Molecules -- 4 PARTITIONING INTO OCTANOL -- 4.1 Tetrad of Equilibria -- 4.2 Conditional Constants -- 4.3 log P Databases -- 4.4 log D -- 4.5 Partitioning of Quaternary Ammonium Drugs -- 4.6 log D of Multiprotic Drugs and the Common-Ion Effect -- 4.7 Summary of Charged-Species Partitioning in Octanol...Water -- 4.8 Ion Pair Absorption of Ionized Drugs"Fact or Fiction? -- 4.9 Micro-log P -- 4.10 HPLC Methods -- 4.11 IAM Chromatography -- 4.12 Liposome Chromatography -- 4.13 Other Chromatographic Methods -- 4.14 pH-Metric log P Method -- 4.15 High-Throughput log P Methods -- 4.16 Octanol...Water log P(N), log P(I), and log D(7.4) "Gold Standard" for Drug Molecules -- 5 PARTITIONING INTO LIPOSOMES -- 5.1 Tetrad of Equilibria and Surface Ion Pairing (SIP) -- 5.2 Databases -- 5.3 Location of Drugs Partitioned into Bilayers -- 5.4 Thermodynamics of Partitioning: En
    標題: Drugs - Design. -
    電子資源: http://dx.doi.org/10.1002/047145026X
    ISBN: 9781601193681 (electronic bk.)
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W9240438 電子資源 11.線上閱覽_V 電子書 EB RS420 .A935 2003eb 一般使用(Normal) 在架 0
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