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Cytochrome P4501A1: Is it a suitable...

Corda, Charlotte Lourdes.

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Cytochrome P4501A1: Is it a suitable biomarker of exposure to dioxin-like persistent organic pollutants and time to pregnancy?

Record Type:	Electronic resources : Monograph/item
Title/Author:	Cytochrome P4501A1: Is it a suitable biomarker of exposure to dioxin-like persistent organic pollutants and time to pregnancy?/
Author:	Corda, Charlotte Lourdes.
Description:	89 p.
Notes:	Source: Masters Abstracts International, Volume: 41-01, page: 0204.
Contained By:	Masters Abstracts International41-01.
Subject:	Health Sciences, Pharmacology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=MQ68806
ISBN:	0612688062

Cytochrome P4501A1: Is it a suitable biomarker of exposure to dioxin-like persistent organic pollutants and time to pregnancy?
Corda, Charlotte Lourdes.

Cytochrome P4501A1: Is it a suitable biomarker of exposure to dioxin-like persistent organic pollutants and time to pregnancy? - 89 p.

Source: Masters Abstracts International, Volume: 41-01, page: 0204.

Thesis (M.Sc.)--University of Toronto (Canada), 2002.

Chemical exposure is linked to reproductive effects in humans. This study was aimed at determining the effects of exposure to persistent organic pollutants on time to pregnancy (TTP). TTP is defined as the time taken from planned intercourse to conception. Polychlorinated dioxins, furans and biphenyls found among the persistent organic pollutants can activate the aryl hydrocarbon receptor (AHR), and induce expression of cytochrome P4501A1 (CYP1A1). The resulting expression of CYP1A1 has been used as a biomarker of exposure to AHR activating ligands. CYP1A1 activity was assayed in full-term placentas from two groups of non-smoking mothers in the Hamilton, Ontario region: those identified as long TTP and those identified as short TTP. CYP1A1 activity was well within the range reported for non-smokers. Our results show no difference between the short and long TTP groups indicating that CYP1A1 may not be a good marker of delayed time to pregnancy, in this group.

ISBN: 0612688062Subjects--Topical Terms:

1017717
Health Sciences, Pharmacology.

Cytochrome P4501A1: Is it a suitable biomarker of exposure to dioxin-like persistent organic pollutants and time to pregnancy?
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100 1 $a Corda, Charlotte Lourdes. $3 1952683
245 1 0 $a Cytochrome P4501A1: Is it a suitable biomarker of exposure to dioxin-like persistent organic pollutants and time to pregnancy?
300 $a 89 p.
500 $a Source: Masters Abstracts International, Volume: 41-01, page: 0204.
500 $a Adviser: Patricia Harper.
502 $a Thesis (M.Sc.)--University of Toronto (Canada), 2002.
520 $a Chemical exposure is linked to reproductive effects in humans. This study was aimed at determining the effects of exposure to persistent organic pollutants on time to pregnancy (TTP). TTP is defined as the time taken from planned intercourse to conception. Polychlorinated dioxins, furans and biphenyls found among the persistent organic pollutants can activate the aryl hydrocarbon receptor (AHR), and induce expression of cytochrome P4501A1 (CYP1A1). The resulting expression of CYP1A1 has been used as a biomarker of exposure to AHR activating ligands. CYP1A1 activity was assayed in full-term placentas from two groups of non-smoking mothers in the Hamilton, Ontario region: those identified as long TTP and those identified as short TTP. CYP1A1 activity was well within the range reported for non-smokers. Our results show no difference between the short and long TTP groups indicating that CYP1A1 may not be a good marker of delayed time to pregnancy, in this group.
590 $a School code: 0779.
650 4 $a Health Sciences, Pharmacology. $3 1017717
650 4 $a Health Sciences, Toxicology. $3 1017752
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