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Probing the role of noise in the sup...

Dorval, Alan Dale, II.

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Probing the role of noise in the superficial medial entorhinal cortex.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Probing the role of noise in the superficial medial entorhinal cortex./
作者:	Dorval, Alan Dale, II.
面頁冊數:	118 p.
附註:	Source: Dissertation Abstracts International, Volume: 65-01, Section: B, page: 0095.
Contained By:	Dissertation Abstracts International65-01B.
標題:	Biology, Neuroscience. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3118805

Probing the role of noise in the superficial medial entorhinal cortex.
Dorval, Alan Dale, II.

Probing the role of noise in the superficial medial entorhinal cortex. - 118 p.

Source: Dissertation Abstracts International, Volume: 65-01, Section: B, page: 0095.

Thesis (Ph.D.)--Boston University, 2004.

We examined stellate and non-stellate cells of the medial entorhinal cortex, laver II. These neuronal classes serve as primary inputs to the hippocampus, a region implicated in learning and memory tasks. During these tasks, the region exhibits an 8 Hz electrical oscillation called the theta rhythm. Stellate cells express theta-rhythmic behavior under many conditions. As principal projectors to the hippocampus, stellates are likely an important source of theta activity in the region, and thus may play a major role in learning and memory. In this work, quantified aspects of the input-output functions in both neuronal classes, and explored one mechanism of theta generation in stellate cells.Subjects--Topical Terms:

1017680
Biology, Neuroscience.

Probing the role of noise in the superficial medial entorhinal cortex.
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245 1 0 $a Probing the role of noise in the superficial medial entorhinal cortex.
300 $a 118 p.
500 $a Source: Dissertation Abstracts International, Volume: 65-01, Section: B, page: 0095.
500 $a Major Professor: John A. White.
502 $a Thesis (Ph.D.)--Boston University, 2004.
520 $a We examined stellate and non-stellate cells of the medial entorhinal cortex, laver II. These neuronal classes serve as primary inputs to the hippocampus, a region implicated in learning and memory tasks. During these tasks, the region exhibits an 8 Hz electrical oscillation called the theta rhythm. Stellate cells express theta-rhythmic behavior under many conditions. As principal projectors to the hippocampus, stellates are likely an important source of theta activity in the region, and thus may play a major role in learning and memory. In this work, quantified aspects of the input-output functions in both neuronal classes, and explored one mechanism of theta generation in stellate cells.
520 $a We constructed a dynamic clamp system, capable of inserting simulated conductances into living membranes. Via dynamic clamp, we examined how in vitro neuronal responses to realistic applied conductance differ from responses to applied current, presented via the more traditional current clamp technique. In both cell classes, conductance allowed for a wider range of possible outputs and reduced the effects of noise on input-output function. These results indicate that conductance-based communication is informationally more efficient than current-based communication. We conclude that when possible, the dynamic clamp technique should be used in place of current clamp.
520 $a We then explored the role that one noise source plays in stellate cell generation of the theta rhythm. Our lab has hypothesized that the noisy gating of a persistent sodium conductance, GNap, is required for stellate cells to exhibit their two stereotyped behaviors: theta-rhythmic subthreshold oscillations, and theta-periodic spikes. GNap blocked GNap pharmacologically, and, via dynamic clamp, introduced a virtual GNap both with and without its natural variance. In the noise-free GNap case, subthreshold oscillatory theta-power was greatly reduced. In contrast, in the realistically noisy GNap case, behavior appeared indistinguishable from control conditions. Thus we confirmed that GNap variance is required for subthreshold oscillations, and demonstrated that noise sources in general can be an essential source of neuronal dynamic.
590 $a School code: 0017.
650 4 $a Biology, Neuroscience. $3 1017680
650 4 $a Engineering, Biomedical. $3 1017684
650 4 $a Biophysics, General. $3 1019105
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773 0 $t Dissertation Abstracts International $g 65-01B.
790 1 0 $a White, John A., $e advisor
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791 $a Ph.D.
792 $a 2004
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3118805