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Large mammalian comparative cardiac ...

Hill, Alexander John.

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Large mammalian comparative cardiac anatomy.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Large mammalian comparative cardiac anatomy./
作者:	Hill, Alexander John.
面頁冊數:	232 p.
附註:	Source: Dissertation Abstracts International, Volume: 64-12, Section: B, page: 6188.
Contained By:	Dissertation Abstracts International64-12B.
標題:	Engineering, Biomedical. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3117537

Large mammalian comparative cardiac anatomy.
Hill, Alexander John.

Large mammalian comparative cardiac anatomy. - 232 p.

Source: Dissertation Abstracts International, Volume: 64-12, Section: B, page: 6188.

Thesis (Ph.D.)--University of Minnesota, 2004.

The use of animal models is critical in understanding cardiovascular physiology and designing new therapeutics targeted at cardiovascular disease. Selection of a specific animal model is based on many different factors including experimental design constraints, anatomy and physiology, cost, manageability of animals in research settings, familiarity of researchers with a specific animal, availability, quantity and quality of obtained data, and relevance to the human condition. Anatomical considerations are an often overlooked, but important, factor in the selection of a proper model for certain types of cardiovascular research because similarities and/or differences will determine the applicability of results to humans. The studies of this thesis project compiled previously published information comparing large mammalian cardiac anatomy, determined the current opinions on large mammalian cardiac anatomy, and critically described details of the anatomy of swine, canine, and ovine hearts, all used as animal models in cardiovascular research. Additionally, unique methodologies for the study of isolated human hearts were described. Specifically, we employed the following on post-mortem, fixed hearts: qualitative observations and three-dimensional quantitative measurements. We also employed the following on in vitro hearts: Visible HeartRTM methodologies employing a 6 mm videoscope (Olympus Optical) and three-dimensional quantitative measurement made with a 3D digital sonomicrometry system (Sonometrics Corp.). The following results were found: (1) Current researchers feel that the pig heart most closely resembles the human heart anatomically, yet continue to use dogs as their primary animal model; (2) Qualitative comparisons between perfusion fixed pig, dog, and sheep hearts were consistent with published literature; (3) Significant differences were found between perfusion fixed pig, dog, and sheep hearts in the right ventricular outflow tract dimension, the left ventricular outflow tract dimension, and the coronary sinus ostium dimensions; (4) Qualitative similarities and differences were seen in the endocardial anatomy when functioning isolated pig, dog, sheep, and human hearts were compared; and (5) Quantitative differences were seen in the curvature of the coronary sinuses of functioning, isolated human, dog, and pig hearts. The findings of this thesis provide further insight into large mammalian comparative cardiac anatomy, which will aid in animal model selection for cardiovascular research.Subjects--Topical Terms:

1017684
Engineering, Biomedical.

Large mammalian comparative cardiac anatomy.
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