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Genetic regulation of cardiac specif...

Keegan, Brian Robert.

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Genetic regulation of cardiac specification in zebrafish.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Genetic regulation of cardiac specification in zebrafish./
Author:	Keegan, Brian Robert.
Description:	308 p.
Notes:	Source: Dissertation Abstracts International, Volume: 64-12, Section: B, page: 5906.
Contained By:	Dissertation Abstracts International64-12B.
Subject:	Biology, Genetics. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3114202

Genetic regulation of cardiac specification in zebrafish.
Keegan, Brian Robert.

Genetic regulation of cardiac specification in zebrafish. - 308 p.

Source: Dissertation Abstracts International, Volume: 64-12, Section: B, page: 5906.

Thesis (Ph.D.)--New York University, 2004.

The embryonic heart is composed of two morphologically and functionally distinct chambers, the atrium and the ventricle. Each chamber contains a layer of muscular myocardium and an endocardial lining. Myocardial and endocardial lineages arise frSubjects--Topical Terms:

1017730
Biology, Genetics.

Genetic regulation of cardiac specification in zebrafish.
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035 $a (UnM)AAI3114202
035 $a AAI3114202
040 $a UnM $c UnM
100 1 $a Keegan, Brian Robert. $3 1950158
245 1 0 $a Genetic regulation of cardiac specification in zebrafish.
300 $a 308 p.
500 $a Source: Dissertation Abstracts International, Volume: 64-12, Section: B, page: 5906.
500 $a Adviser: Deborah Yelon.
502 $a Thesis (Ph.D.)--New York University, 2004.
520 $a The embryonic heart is composed of two morphologically and functionally distinct chambers, the atrium and the ventricle. Each chamber contains a layer of muscular myocardium and an endocardial lining. Myocardial and endocardial lineages arise fr
520 $a A fate map of zebrafish cardiac progenitors, constructed using caged fluorescein, demonstrates that ventricular and atrial myocardial progenitors are spatially organized prior to gastrulation. Specifically, ventricular myocardial progenitors are
520 $a In addition to Nodal, the zebrafish pandora and foggy genes are required to promote myocardial development. pandora encodes Spt6 and foggy encodes Spt5, both of which act as transcription elongation factors. Real-time RT-PCR analysis indicates
520 $a Selection of cardiac progenitors is likely to involve a balance of inductive and repressive influences. Genetic and pharmacological manipulation of retinoic acid signaling demonstrates that this pathway acts during gastrulation to restrict the n
520 $a Altogether, these results contribute to our understanding of how the heart field is organized and which molecular cues regulate that organization. They also raise intriguing questions about how multiple signals are integrated to regulate cardiac
590 $a School code: 0146.
650 4 $a Biology, Genetics. $3 1017730
690 $a 0369
710 2 0 $a New York University. $3 515735
773 0 $t Dissertation Abstracts International $g 64-12B.
790 1 0 $a Yelon, Deborah, $e advisor
790 $a 0146
791 $a Ph.D.
792 $a 2004
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3114202