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Noble metal nanocrystals: Synthesis...

Jin, Rongchao.

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Noble metal nanocrystals: Synthesis, optical properties, and biological applications.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Noble metal nanocrystals: Synthesis, optical properties, and biological applications./
Author:	Jin, Rongchao.
Description:	226 p.
Notes:	Source: Dissertation Abstracts International, Volume: 65-01, Section: B, page: 0214.
Contained By:	Dissertation Abstracts International65-01B.
Subject:	Chemistry, Inorganic. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3118553

Noble metal nanocrystals: Synthesis, optical properties, and biological applications.
Jin, Rongchao.

Noble metal nanocrystals: Synthesis, optical properties, and biological applications. - 226 p.

Source: Dissertation Abstracts International, Volume: 65-01, Section: B, page: 0214.

Thesis (Ph.D.)--Northwestern University, 2003.

The primary goal of this thesis research was to synthesize new types of metal nanocrystals, evaluate their fundamental optical properties, and develop biological applications based upon properties that offer advantages in terms of sensitivity, selectivity, and multiplexing capabilities. Noble metal nanocrystals are particularly important because of their chemical stability and fascinating optical properties that can be tailored through control over particle size, shape, composition, and morphology.Subjects--Topical Terms:

517253
Chemistry, Inorganic.

Noble metal nanocrystals: Synthesis, optical properties, and biological applications.
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035 $a (UnM)AAI3118553
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100 1 $a Jin, Rongchao. $3 1948835
245 1 0 $a Noble metal nanocrystals: Synthesis, optical properties, and biological applications.
300 $a 226 p.
500 $a Source: Dissertation Abstracts International, Volume: 65-01, Section: B, page: 0214.
500 $a Adviser: Chad A. Mirkin.
502 $a Thesis (Ph.D.)--Northwestern University, 2003.
520 $a The primary goal of this thesis research was to synthesize new types of metal nanocrystals, evaluate their fundamental optical properties, and develop biological applications based upon properties that offer advantages in terms of sensitivity, selectivity, and multiplexing capabilities. Noble metal nanocrystals are particularly important because of their chemical stability and fascinating optical properties that can be tailored through control over particle size, shape, composition, and morphology.
520 $a The first part of this dissertation presents a photochemical method for synthesizing triangular silver nanoprisms in the form of colloidal suspensions. This photo-mediated route has led to a colloid with unusual optical properties that directly relate to particle shape and size. Theoretical calculations allowed for the assignment of the nanoprism plasmon bands and the identification of two distinct quadrupole plasmon resonances. Importantly, the nanoprism edge length (thickness remains constant) can be controlled over the 30--150 nm range by excitation wavelength. This work provides the first demonstration of the use of plasmon excitation as a chemical tool to provide control over nanoparticle growth and, ultimately, particle size and shape.
520 $a The second part of this thesis focuses on the development of nanoparticle-based multiplexed DNA detection systems. The first strategy is to exploit the optical properties of coreshell nanoparticles that consist of a silver core and a thin coating of gold. Silver particles have outstanding optical properties but poor chemical stability. This new type of coreshell particle yields a novel nanoparticle composition with the optical properties of silver but the chemical stability of gold. The second approach utilizes pure gold nanoparticles that are functionalized with different Raman-dye labeled oligonucleotides. The individual Raman spectroscopic fingerprints (with narrow bands) of the particle probes, which can be identified after silver enhancing via surface-enhanced Raman scattering (SERS) spectroscopy, are used to label and identify different DNA targets.
520 $a Finally, we systematically investigated what controls the melting properties of DNA-linked nanoparticle assemblies. The experimental data, coupled with theoretical modeling, identified a cooperative DNA melting mechanism that attributes the sharp melting to two key factors: the presence of multiple DNA linkers between nanoparticles and a decrease in the melting temperature as DNA duplexes melt due to a concomitant reduction in local salt concentration. This cooperative melting effect originates from short-range duplex-to-duplex interactions and is independent of DNA sequences and nanostructure type. Importantly, it is this sharp melting transition that leads to the ultrahigh selectivity observed in assays based upon these types of probes.
590 $a School code: 0163.
650 4 $a Chemistry, Inorganic. $3 517253
650 4 $a Chemistry, Physical. $3 560527
650 4 $a Chemistry, Biochemistry. $3 1017722
690 $a 0488
690 $a 0494
690 $a 0487
710 2 0 $a Northwestern University. $3 1018161
773 0 $t Dissertation Abstracts International $g 65-01B.
790 1 0 $a Mirkin, Chad A., $e advisor
790 $a 0163
791 $a Ph.D.
792 $a 2003
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3118553