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Influence of lipoprotein lipids and ...

Gopinathannair, Rakesh.

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Influence of lipoprotein lipids and apolipoprotein E gene polymorphisms on coagulation factor VIII changes with six months of aerobic exercise training.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Influence of lipoprotein lipids and apolipoprotein E gene polymorphisms on coagulation factor VIII changes with six months of aerobic exercise training./
作者:	Gopinathannair, Rakesh.
面頁冊數:	89 p.
附註:	Source: Masters Abstracts International, Volume: 42-04, page: 1253.
Contained By:	Masters Abstracts International42-04.
標題:	Health Sciences, Recreation. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1417594

Influence of lipoprotein lipids and apolipoprotein E gene polymorphisms on coagulation factor VIII changes with six months of aerobic exercise training.
Gopinathannair, Rakesh.

Influence of lipoprotein lipids and apolipoprotein E gene polymorphisms on coagulation factor VIII changes with six months of aerobic exercise training. - 89 p.

Source: Masters Abstracts International, Volume: 42-04, page: 1253.

Thesis (M.A.)--University of Maryland College Park, 2004.

Elevated plasma factor VIII antigen (FVIII:Ag) level is an independent risk factor for coronary artery disease. Aerobic training improves cardiovascular risk and improvement in coagulation profile might be a potential contributory mechanism. Available evidence suggests that plasma lipoprotein-lipid levels and lipid-related genotypes might have a regulatory effect on plasma FVIII:Ag levels. We assessed the effects of APO E gene polymorphisms and plasma lipoprotein-lipid changes on plasma FVIII:Ag changes with 6 mo of standardized aerobic training in 44 sedentary, 50--75 year old men and women with different APO E genotypes. Plasma FVIII:Ag levels, lipoprotein-lipid levels, VO2 max, and intra-abdominal fat (CTIA) were estimated before and after 6 mo of training. Plasma FVIII:Ag levels showed an increase of 3.5% (152.5 +/- 6.7% to 156.0 +/- 6.1%, P = 0.290) with exercise training. FVIII:Ag levels were positively correlated to CTIA at baseline (r = 0.30) and after training (r = 0.37). There was no significant association between FVIII:Ag levels and APO E genotype, before and after covarying for training-induced changes in plasma lipoprotein-lipids. In conclusion, the effect of regular aerobic exercise training on plasma FVIII:Ag levels appears small and clinically insignificant when compared to the clear and beneficial effects on lipoprotein-lipid profile and body composition. Truncal obesity may be a significant factor modulating baseline plasma FVIII:Ag levels and their response to training.Subjects--Topical Terms:

1018003
Health Sciences, Recreation.

Influence of lipoprotein lipids and apolipoprotein E gene polymorphisms on coagulation factor VIII changes with six months of aerobic exercise training.
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245 1 0 $a Influence of lipoprotein lipids and apolipoprotein E gene polymorphisms on coagulation factor VIII changes with six months of aerobic exercise training.
300 $a 89 p.
500 $a Source: Masters Abstracts International, Volume: 42-04, page: 1253.
500 $a Chair: James M. Hagberg.
502 $a Thesis (M.A.)--University of Maryland College Park, 2004.
520 $a Elevated plasma factor VIII antigen (FVIII:Ag) level is an independent risk factor for coronary artery disease. Aerobic training improves cardiovascular risk and improvement in coagulation profile might be a potential contributory mechanism. Available evidence suggests that plasma lipoprotein-lipid levels and lipid-related genotypes might have a regulatory effect on plasma FVIII:Ag levels. We assessed the effects of APO E gene polymorphisms and plasma lipoprotein-lipid changes on plasma FVIII:Ag changes with 6 mo of standardized aerobic training in 44 sedentary, 50--75 year old men and women with different APO E genotypes. Plasma FVIII:Ag levels, lipoprotein-lipid levels, VO2 max, and intra-abdominal fat (CTIA) were estimated before and after 6 mo of training. Plasma FVIII:Ag levels showed an increase of 3.5% (152.5 +/- 6.7% to 156.0 +/- 6.1%, P = 0.290) with exercise training. FVIII:Ag levels were positively correlated to CTIA at baseline (r = 0.30) and after training (r = 0.37). There was no significant association between FVIII:Ag levels and APO E genotype, before and after covarying for training-induced changes in plasma lipoprotein-lipids. In conclusion, the effect of regular aerobic exercise training on plasma FVIII:Ag levels appears small and clinically insignificant when compared to the clear and beneficial effects on lipoprotein-lipid profile and body composition. Truncal obesity may be a significant factor modulating baseline plasma FVIII:Ag levels and their response to training.
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