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Computational fluid dynamic assessme...

Masters, Jonathan Charles.

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Computational fluid dynamic assessment of the total cavopulmonary connection.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Computational fluid dynamic assessment of the total cavopulmonary connection./
作者:	Masters, Jonathan Charles.
面頁冊數:	127 p.
附註:	Source: Dissertation Abstracts International, Volume: 64-04, Section: B, page: 1814.
Contained By:	Dissertation Abstracts International64-04B.
標題:	Engineering, Biomedical. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3086572

Computational fluid dynamic assessment of the total cavopulmonary connection.
Masters, Jonathan Charles.

Computational fluid dynamic assessment of the total cavopulmonary connection. - 127 p.

Source: Dissertation Abstracts International, Volume: 64-04, Section: B, page: 1814.

Thesis (Ph.D.)--The University of North Carolina at Chapel Hill, 2003.

Each year the incidence of children born with complex congenital heart defects amounts to 8 out of every 1000 live-births. About 20% of these cases take the form of a univentricular heart where there is only one functional ventricle. Oxygenated and unoxygenated blood mix in the heart and then this mixture is pumped to the pulmonary and systemic circulations. Because of this, the right heart atriopulmonary pathway and, therefore, the cardiopulmonary function, is impaired. One type of modification is carried out by bypassing the ventricle on the pulmonary side, thus resulting in a cardiovascular system in which the systemic and pulmonary circulations are separate, but only one ventricle is included. Fontan and Baudet implemented a successful atriopulmonary connection in 1971 and Fontan since has become the generic term applied to procedures to repair the blood flow pathway. Currently, the most commonly used connection is the total cavopulmonary connection (TCPC). This connection is carried out in two stages. In the first the superior vena cava (SVC) is transected and attached to the right pulmonary artery (RPA) by an end-to-side anastomosis. Then, in the second stage, the inferior vena cava (IVC) is attached to the right pulmonary artery by an end-to-side anastomosis. Since the right heart has been removed from circulation, the cardiovascular load is placed completely on the left heart. Major long-term problems associated with the TCPC are pulmonary hypotension, right lung isolation from hepatic blood, and thromboembolic complications. The research presented in this dissertation focuses on minimizing the effects of these three factors by employing a compliant-walled computational fluid dynamic model to better understand the factors that cause them.Subjects--Topical Terms:

1017684
Engineering, Biomedical.

Computational fluid dynamic assessment of the total cavopulmonary connection.
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502 $a Thesis (Ph.D.)--The University of North Carolina at Chapel Hill, 2003.
520 $a Each year the incidence of children born with complex congenital heart defects amounts to 8 out of every 1000 live-births. About 20% of these cases take the form of a univentricular heart where there is only one functional ventricle. Oxygenated and unoxygenated blood mix in the heart and then this mixture is pumped to the pulmonary and systemic circulations. Because of this, the right heart atriopulmonary pathway and, therefore, the cardiopulmonary function, is impaired. One type of modification is carried out by bypassing the ventricle on the pulmonary side, thus resulting in a cardiovascular system in which the systemic and pulmonary circulations are separate, but only one ventricle is included. Fontan and Baudet implemented a successful atriopulmonary connection in 1971 and Fontan since has become the generic term applied to procedures to repair the blood flow pathway. Currently, the most commonly used connection is the total cavopulmonary connection (TCPC). This connection is carried out in two stages. In the first the superior vena cava (SVC) is transected and attached to the right pulmonary artery (RPA) by an end-to-side anastomosis. Then, in the second stage, the inferior vena cava (IVC) is attached to the right pulmonary artery by an end-to-side anastomosis. Since the right heart has been removed from circulation, the cardiovascular load is placed completely on the left heart. Major long-term problems associated with the TCPC are pulmonary hypotension, right lung isolation from hepatic blood, and thromboembolic complications. The research presented in this dissertation focuses on minimizing the effects of these three factors by employing a compliant-walled computational fluid dynamic model to better understand the factors that cause them.
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