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Mother to child transmission of HIV-...

Kittinunvorakoon, Chonticha.

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Mother to child transmission of HIV-1 in Bangkok, Thailand: The effect of maternal humoral immune responses and virus characteristics.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Mother to child transmission of HIV-1 in Bangkok, Thailand: The effect of maternal humoral immune responses and virus characteristics./
Author:	Kittinunvorakoon, Chonticha.
Description:	156 p.
Notes:	Source: Dissertation Abstracts International, Volume: 65-02, Section: B, page: 0686.
Contained By:	Dissertation Abstracts International65-02B.
Subject:	Health Sciences, Public Health. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3121554

Mother to child transmission of HIV-1 in Bangkok, Thailand: The effect of maternal humoral immune responses and virus characteristics.
Kittinunvorakoon, Chonticha.

Mother to child transmission of HIV-1 in Bangkok, Thailand: The effect of maternal humoral immune responses and virus characteristics. - 156 p.

Source: Dissertation Abstracts International, Volume: 65-02, Section: B, page: 0686.

Thesis (Ph.D.)--University of California, Berkeley, 2003.

Despite the success of AZT treatments in reducing the risk of vertical transmission of HIV, the number of HIV infections in children worldwide is still increasing because most resource-poor countries cannot afford to implement these treatments. Therefore, it remains important to develop additional universally applicable and feasible intervention strategies for prevention of mother-to-child transmission of HIV.Subjects--Topical Terms:

1017659
Health Sciences, Public Health.

Mother to child transmission of HIV-1 in Bangkok, Thailand: The effect of maternal humoral immune responses and virus characteristics.
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035 $a (UnM)AAI3121554
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040 $a UnM $c UnM
100 1 $a Kittinunvorakoon, Chonticha. $3 1947455
245 1 0 $a Mother to child transmission of HIV-1 in Bangkok, Thailand: The effect of maternal humoral immune responses and virus characteristics.
300 $a 156 p.
500 $a Source: Dissertation Abstracts International, Volume: 65-02, Section: B, page: 0686.
500 $a Chair: Gertrude C. Buehring.
502 $a Thesis (Ph.D.)--University of California, Berkeley, 2003.
520 $a Despite the success of AZT treatments in reducing the risk of vertical transmission of HIV, the number of HIV infections in children worldwide is still increasing because most resource-poor countries cannot afford to implement these treatments. Therefore, it remains important to develop additional universally applicable and feasible intervention strategies for prevention of mother-to-child transmission of HIV.
520 $a In a nested case-control study within a clinical trial in Bangkok, Thailand, HIV-infected pregnant women who had not received anti-retroviral drug therapy were studied to seek factors that might be relevant to prevention of transmission of HIV to their infants. The study population includes 28 transmitters (women who transmitted HIV to their infants) and 56 non-transmitters (women who did not transmit HIV to their infants). The maternal HIV-specific humoral immune responses and viral characteristics were examined and compared between transmitters and non-transmitters.
520 $a The data demonstrated that the maternal HIV-specific humoral immune response, as measured by HIV envelope peptide binding antibody (Ab) titers, heterologous neutralizing Ab titer against a laboratory-adapted HIV strain MN, heterologous neutralizing Ab titers against HIV primary isolates, autologous neutralizing Ab titer, and maternal viral envelope quasispecies diversity, were not associated with the risk of vertical transmission of HIV. Maternal HIV isolates were examined for their co-receptor preference and replicating characteristics. There was no association between maternal co-receptor usage and the risk of vertical transmission of HIV. The majority of maternal isolates were NSI viruses and used CCR5 as a co-receptor. The only factor to show a significant association with mother-to-child transmission of HIV was viral replicative capacity.
520 $a These results suggest that the maternal HIV-specific humoral immune response may play a less critical role in modulating the risk of mother-to-child transmission of HIV than was previously supposed, and mothers harboring R5 viruses do not have a higher risk of vertical transmission of HIV as was previously proposed. However, mothers harboring viruses with higher replicative capacity are more likely to transmit HIV to their infants.
590 $a School code: 0028.
650 4 $a Health Sciences, Public Health. $3 1017659
650 4 $a Health Sciences, Immunology. $3 1017716
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710 2 0 $a University of California, Berkeley. $3 687832
773 0 $t Dissertation Abstracts International $g 65-02B.
790 1 0 $a Buehring, Gertrude C., $e advisor
790 $a 0028
791 $a Ph.D.
792 $a 2003
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3121554