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Epidemiology of hepatitis C virus in...

Thaikruea, Lakkana.

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Epidemiology of hepatitis C virus infection among blood donors in northern Thailand.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Epidemiology of hepatitis C virus infection among blood donors in northern Thailand./
作者:	Thaikruea, Lakkana.
面頁冊數:	152 p.
附註:	Source: Dissertation Abstracts International, Volume: 64-02, Section: B, page: 0677.
Contained By:	Dissertation Abstracts International64-02B.
標題:	Health Sciences, Public Health. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3080779

Epidemiology of hepatitis C virus infection among blood donors in northern Thailand.
Thaikruea, Lakkana.

Epidemiology of hepatitis C virus infection among blood donors in northern Thailand. - 152 p.

Source: Dissertation Abstracts International, Volume: 64-02, Section: B, page: 0677.

Thesis (Ph.D.)--The Johns Hopkins University, 2003.

<italic>Objectives</italic>. To determine the potential risk factors for HCV infection, HCV genotype distribution, and the relationship between HCV genotypes and the routes of transmission among blood donors in northern Thailand.Subjects--Topical Terms:

1017659
Health Sciences, Public Health.

Epidemiology of hepatitis C virus infection among blood donors in northern Thailand.
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100 1 $a Thaikruea, Lakkana. $3 1947303
245 1 0 $a Epidemiology of hepatitis C virus infection among blood donors in northern Thailand.
300 $a 152 p.
500 $a Source: Dissertation Abstracts International, Volume: 64-02, Section: B, page: 0677.
500 $a Adviser: Kenrad E. Nelson.
502 $a Thesis (Ph.D.)--The Johns Hopkins University, 2003.
520 $a <italic>Objectives</italic>. To determine the potential risk factors for HCV infection, HCV genotype distribution, and the relationship between HCV genotypes and the routes of transmission among blood donors in northern Thailand.
520 $a <italic>Population</italic>. The donors and spouses aged at least 18 years at the time of donation or recruitment who resided in the north and donated blood during January, 2001 to June 2002 were eligible for the study.
520 $a <italic>Methods</italic>. A single masked matched case-control study was conducted. The confirmed cases were eligible cases who were EIA-3 with any positive for HCV of the following confirmatory test; PCR, RIBA-3, or high cut-off repeat EIA-3 from different companies.
520 $a <italic>Results</italic>. 157 of 175 cases were PCR positive. There were 166 confirmed cases and 329 matched controls. IDU was strongly associated with HCV infection (OR: 107.57). Based on multivariate analysis among non-IDU (107 matched sets), the major statistically significant were history of blood transfusion (22.77), immediate blood relatives ever had hepatitis/jaundice (4.37), having at least 6 lifetime sexual partners (2.66), and previous blood donation (0.89). Six of 45 case-spouses but none of 44 control-spouses had HCV infection. 156 could be identified the genotypes. Consensus phylogenic tree showed clustering of sequences within subtypes with high bootstrap values. The genotypes distribution was comprised of type 3 (36.5%), 6 (34.7%) and 1 (28.8%). Participants infected with type 3 had significantly higher ALT level than other types. Type 6 was more diverse than other types were. The highest prevalence of genotype among IDU who reported the last injecting drugs within the past 5 years, 5–9 years, and at least 10 years were type 3, 1 and 6, subsequently (p-value 0.045). No particular genotype was statistically associated with any route of infection.
520 $a <italic>Conclusion</italic>. History of IDU and prior blood transfusion were the important risk factors associated with HCV infection. Repeat blood donors were significantly less likely to have HCV infection. Improved process for self-deferral of blood donors with a history of IDU and transfusion of unscreened blood and active recruitment of repeat donors who have previously tested negative for HCV could reduce the number of HCV positive donor and improve transfusion safety. The possibility of the more recent introduction of genotype 3 and induced liver enzymes in donors infected with type 3 should be further evaluated. (Abstract shortened by UMI.)
590 $a School code: 0098.
650 4 $a Health Sciences, Public Health. $3 1017659
650 4 $a Biology, Microbiology. $3 1017734
690 $a 0573
690 $a 0410
710 2 0 $a The Johns Hopkins University. $3 1017431
773 0 $t Dissertation Abstracts International $g 64-02B.
790 1 0 $a Nelson, Kenrad E., $e advisor
790 $a 0098
791 $a Ph.D.
792 $a 2003
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3080779