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Spatiotemporal dynamics of protein k...

Violin, Jonathan D.

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Spatiotemporal dynamics of protein kinase C signaling.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Spatiotemporal dynamics of protein kinase C signaling./
Author:	Violin, Jonathan D.
Description:	166 p.
Notes:	Source: Dissertation Abstracts International, Volume: 64-06, Section: B, page: 2613.
Contained By:	Dissertation Abstracts International64-06B.
Subject:	Health Sciences, Pharmacology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3094617

Spatiotemporal dynamics of protein kinase C signaling.
Violin, Jonathan D.

Spatiotemporal dynamics of protein kinase C signaling. - 166 p.

Source: Dissertation Abstracts International, Volume: 64-06, Section: B, page: 2613.

Thesis (Ph.D.)--University of California, San Diego, 2003.

Despite many advances in contemporary pharmacology and cell biology, there still exists an epistemological chasm between data gathered biochemically and data gathered from whole animal or tissue. In complex systems of signal transduction, such as for Protein Kinase C (PKC), the lack of precise information at the cellular level can preclude meaningful integration of biochemical and animal data into comprehensive understanding of a signaling system. This dissertation extends knowledge gained from previous PKC research to live cell experiments using technologies based upon <italic>A. Victoria</italic> Green Fluorescent Protein. Specifically, this dissertation shows that genetically encoded fluorescent reporters for PKC conformational changes, lipid raft microdomains, and PKC substrate phosphorylation provide molecular detail to PKC function in living cells. The results presented here show a remarkable fidelity of PKC signal transduction to dynamic regulation, and suggest that such methods may be applicable to a wide variety of kinase signals in living cells. We describe PKC as a signal integrator that allows cells to process rapidly changing environmental cues with high temporal precision, providing cells with a mechanism for high-content information in the form of dynamic phosphorylation.Subjects--Topical Terms:

1017717
Health Sciences, Pharmacology.

Spatiotemporal dynamics of protein kinase C signaling.
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100 1 $a Violin, Jonathan D. $3 1947034
245 1 0 $a Spatiotemporal dynamics of protein kinase C signaling.
300 $a 166 p.
500 $a Source: Dissertation Abstracts International, Volume: 64-06, Section: B, page: 2613.
500 $a Chair: Alexandra C. Newton.
502 $a Thesis (Ph.D.)--University of California, San Diego, 2003.
520 $a Despite many advances in contemporary pharmacology and cell biology, there still exists an epistemological chasm between data gathered biochemically and data gathered from whole animal or tissue. In complex systems of signal transduction, such as for Protein Kinase C (PKC), the lack of precise information at the cellular level can preclude meaningful integration of biochemical and animal data into comprehensive understanding of a signaling system. This dissertation extends knowledge gained from previous PKC research to live cell experiments using technologies based upon <italic>A. Victoria</italic> Green Fluorescent Protein. Specifically, this dissertation shows that genetically encoded fluorescent reporters for PKC conformational changes, lipid raft microdomains, and PKC substrate phosphorylation provide molecular detail to PKC function in living cells. The results presented here show a remarkable fidelity of PKC signal transduction to dynamic regulation, and suggest that such methods may be applicable to a wide variety of kinase signals in living cells. We describe PKC as a signal integrator that allows cells to process rapidly changing environmental cues with high temporal precision, providing cells with a mechanism for high-content information in the form of dynamic phosphorylation.
590 $a School code: 0033.
650 4 $a Health Sciences, Pharmacology. $3 1017717
650 4 $a Biology, Cell. $3 1017686
650 4 $a Biology, Molecular. $3 1017719
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710 2 0 $a University of California, San Diego. $3 1018093
773 0 $t Dissertation Abstracts International $g 64-06B.
790 1 0 $a Newton, Alexandra C., $e advisor
790 $a 0033
791 $a Ph.D.
792 $a 2003
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3094617