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Diabetes mellitus in American Indian...

Sambo, Boureima Hama.

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Diabetes mellitus in American Indian children and adolescents.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Diabetes mellitus in American Indian children and adolescents./
作者:	Sambo, Boureima Hama.
面頁冊數:	196 p.
附註:	Source: Dissertation Abstracts International, Volume: 64-06, Section: B, page: 2627.
Contained By:	Dissertation Abstracts International64-06B.
標題:	Health Sciences, Public Health. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3095290

Diabetes mellitus in American Indian children and adolescents.
Sambo, Boureima Hama.

Diabetes mellitus in American Indian children and adolescents. - 196 p.

Source: Dissertation Abstracts International, Volume: 64-06, Section: B, page: 2627.

Thesis (Ph.D.)--The University of Oklahoma Health Sciences Center, 2003.

A case-control study was conducted (1) to describe early onset diabetes mellitus (DM) in American Indian children and adolescents and (2) to identify risk factors for early onset Type 2 DM in Indian youth.Subjects--Topical Terms:

1017659
Health Sciences, Public Health.

Diabetes mellitus in American Indian children and adolescents.
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245 1 0 $a Diabetes mellitus in American Indian children and adolescents.
300 $a 196 p.
500 $a Source: Dissertation Abstracts International, Volume: 64-06, Section: B, page: 2627.
500 $a Major Professors: June E. Eichner; Lorraine H. Malcoe.
502 $a Thesis (Ph.D.)--The University of Oklahoma Health Sciences Center, 2003.
520 $a A case-control study was conducted (1) to describe early onset diabetes mellitus (DM) in American Indian children and adolescents and (2) to identify risk factors for early onset Type 2 DM in Indian youth.
520 $a This study included a total 150 incident and prevalent cases of DM, which were identified through the review of existing medical records at several Indian Health Service (IHS) and tribal health facilities in Oklahoma. Thirteen percent were Type 1 DM, 67% were Type 2 DM, and 20% were a new group of DM that we called Type 3 DM. This third category was needed for DM cases that showed evidence of normal or elevated levels of endogenous insulin and C-peptide and the repeated presence of islet cell antibodies (ICA). Controls consisted of 130 patients randomly selected from the same facilities who were frequency matched on age.
520 $a The odds ratios (OR) and 95% confidence intervals (CI) for the most significant contributing independent predictors of Type 2 DM in children and adolescents (controlling for other factors) were: overweight and at risk of overweight (OR = 21.0; 95% CI, 9--77), maternal excessive weight gain during pregnancy (OR = 17.3; 95% CI, 5.6--89.9), maternal pre-pregnancy obesity (OR = 14.3; 95% CI, 5.3--73.3), bottle and formula feeding (OR = 13.7; 95% CI, 5.1--37.2), gestational diabetes (OR = 9.0; 95 CI, 3.8--31.6), increasing maternal pre-pregnancy age (OR = 1.2; 95% CI, 1.06--1.44), and the increase in apgar score (OR = 0.18; 95% CI, 0.05--0.5).
520 $a These results reveal a 44% increase in the odds for developing Type 2 DM for each one-kg/m2 in excess pre-pregnancy weight. Similarly, a 50% increase in DM risk occurred with each kilogram of excess weight gain during pregnancy. Thus, the use of educational tools for promoting healthy lifestyles before, during and after pregnancy is of particular importance for American Indian communities. Reducing maternal obesity and promoting breastfeeding could radically alter the present risk for the Type 2 DM in American children and adolescents.
520 $a A more complex picture is evolving in regard to this new epidemic of diabetes. The ICAs and the extremely elevated fasting blood glucose and A1c levels found at diagnosis of Type 2 DM in the present study may be markers for the evolving clinical condition and fast progression to diabetes in Indian youth. We appear to be faced with a new syndrome, which might be aptly labeled the Glycemic Fetal Syndrome (GFS), as many of the major contributing risk factors for Type 2 DM in children may occur pre-pregnancy and during pregnancy.
590 $a School code: 0361.
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790 1 0 $a Malcoe, Lorraine H., $e advisor
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