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Manipulating and measuring the physi...

D'Onofrio, Terrence Gregory.

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Manipulating and measuring the physical properties and local structure of biomembranes.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Manipulating and measuring the physical properties and local structure of biomembranes./
作者:	D'Onofrio, Terrence Gregory.
面頁冊數:	159 p.
附註:	Source: Dissertation Abstracts International, Volume: 64-07, Section: B, page: 3294.
Contained By:	Dissertation Abstracts International64-07B.
標題:	Chemistry, Physical. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3098227

Manipulating and measuring the physical properties and local structure of biomembranes.
D'Onofrio, Terrence Gregory.

Manipulating and measuring the physical properties and local structure of biomembranes. - 159 p.

Source: Dissertation Abstracts International, Volume: 64-07, Section: B, page: 3294.

Thesis (Ph.D.)--The Pennsylvania State University, 2003.

Local composition, structure, morphology, and phase are interrelated in lipid bilayer membranes. This gives us the opportunity to control one or more of these properties by manipulating others. These properties are important in biology for endocytosis and exocytosis, lipid raft formation, and lateral diffusion of membrane-bound species. We discuss methods of preparing two-component/two-phase giant unilamellar vesicles as models for biological membranes and we detail the development of tools to measure and to control the properties of these membranes. We investigate these relationships with combinations of simultaneous two-color widefield fluorescence imaging, three-dimensional rendering of vesicle domains, and manipulation of the vesicle morphology and measurement of the material properties via micropipette aspiration. We demonstrate microtubule degradation induced by free radicals that penetrate the membrane. Such systematic measurements are critical in understanding the roles of individual membrane components and their aggregate effects on the behavior of the whole system.Subjects--Topical Terms:

560527
Chemistry, Physical.

Manipulating and measuring the physical properties and local structure of biomembranes.
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520 $a Local composition, structure, morphology, and phase are interrelated in lipid bilayer membranes. This gives us the opportunity to control one or more of these properties by manipulating others. These properties are important in biology for endocytosis and exocytosis, lipid raft formation, and lateral diffusion of membrane-bound species. We discuss methods of preparing two-component/two-phase giant unilamellar vesicles as models for biological membranes and we detail the development of tools to measure and to control the properties of these membranes. We investigate these relationships with combinations of simultaneous two-color widefield fluorescence imaging, three-dimensional rendering of vesicle domains, and manipulation of the vesicle morphology and measurement of the material properties via micropipette aspiration. We demonstrate microtubule degradation induced by free radicals that penetrate the membrane. Such systematic measurements are critical in understanding the roles of individual membrane components and their aggregate effects on the behavior of the whole system.
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