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Development of novel PLGA contrast a...

El-Sherif, Dalia.

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Development of novel PLGA contrast agents for use as ultrasound targeted drug delivery vehicles.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Development of novel PLGA contrast agents for use as ultrasound targeted drug delivery vehicles./
Author:	El-Sherif, Dalia.
Description:	186 p.
Notes:	Source: Dissertation Abstracts International, Volume: 64-06, Section: B, page: 2774.
Contained By:	Dissertation Abstracts International64-06B.
Subject:	Engineering, Biomedical. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3094667

Development of novel PLGA contrast agents for use as ultrasound targeted drug delivery vehicles.
El-Sherif, Dalia.

Development of novel PLGA contrast agents for use as ultrasound targeted drug delivery vehicles. - 186 p.

Source: Dissertation Abstracts International, Volume: 64-06, Section: B, page: 2774.

Thesis (Ph.D.)--Drexel University, 2003.

Ultrasound is limited in its ability to distinguish between diseased and normal tissue. This limitation has led to the development of contrast agents. We have produced novel air-filled microcapsules of poly (lactic-co-glycolic) acid (PLGA/PLA) that work well as ultrasound contrast agents. The agent demonstrated acoustic enhancements up to 24 dB in vitro and in vivo. Furthermore, in vivo Doppler enhancements of a rabbit kidney were reported with injections of a 0.1mL/kg dose. The rabbits did not show any side effects from multiple injections (24) of the agent.Subjects--Topical Terms:

1017684
Engineering, Biomedical.

Development of novel PLGA contrast agents for use as ultrasound targeted drug delivery vehicles.
LDR:03088nmm 2200337 4500 001 1858964
005 20041020095007.5
008 130614s2003 eng d
035 $a (UnM)AAI3094667
035 $a AAI3094667
040 $a UnM $c UnM
100 1 $a El-Sherif, Dalia. $3 1946631
245 1 0 $a Development of novel PLGA contrast agents for use as ultrasound targeted drug delivery vehicles.
300 $a 186 p.
500 $a Source: Dissertation Abstracts International, Volume: 64-06, Section: B, page: 2774.
500 $a Adviser: Margaret Wheatley.
502 $a Thesis (Ph.D.)--Drexel University, 2003.
520 $a Ultrasound is limited in its ability to distinguish between diseased and normal tissue. This limitation has led to the development of contrast agents. We have produced novel air-filled microcapsules of poly (lactic-co-glycolic) acid (PLGA/PLA) that work well as ultrasound contrast agents. The agent demonstrated acoustic enhancements up to 24 dB in vitro and in vivo. Furthermore, in vivo Doppler enhancements of a rabbit kidney were reported with injections of a 0.1mL/kg dose. The rabbits did not show any side effects from multiple injections (24) of the agent.
520 $a The contrast agent was fabricated by modifying a double emulsion method to encapsulate sublimable materials in the oil and aqueous phases. The encapsulated materials were then sublimed, leaving a void in their place.
520 $a The degradation of contrast agents was found to be closely related to both capsule morphology and insonation frequency at which they were exposed. Agent degradation was monitored by high performance liquid chromatography (HPLC). Amounts of lactic and glycolic acids produced were quantified. Glycolic acid repeat units showed a greater degradation rate than lactic acid units.
520 $a Additional in vitro studies were carried out to further optimize and characterize the agent. The surfactant solution temperature was found to play an important role in agent morphology and acoustic response. An attenuation study indicated that their resonance frequency was &sim;2 MHz. Furthermore, in vivo and in vitro studies concluded that the 50:50 PLGA agent is temperature sensitive, lasting up to 20 min at 25°C (minimal loss of signal (4 dB), while at 37°C the signal drops close to baseline with in the first 5 minutes. It was concluded that fabrication of the contrast agent with a more hydrophobic polymer extends its acoustic time response.
520 $a Preliminary drug delivery and targeting studies were also investigated. The reported results are promising and lay the foundation for future work.
520 $a This research has led to the development of novel PLGA/PLA contrast agents that have shown potential use for targeted drug delivery vehicles.
590 $a School code: 0065.
650 4 $a Engineering, Biomedical. $3 1017684
650 4 $a Chemistry, Polymer. $3 1018428
650 4 $a Biophysics, Medical. $3 1017681
690 $a 0541
690 $a 0495
690 $a 0760
710 2 0 $a Drexel University. $3 1018434
773 0 $t Dissertation Abstracts International $g 64-06B.
790 1 0 $a Wheatley, Margaret, $e advisor
790 $a 0065
791 $a Ph.D.
792 $a 2003
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3094667