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Synthesis of an injectable biodegrad...

Behravesh, Esfandiar.

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Synthesis of an injectable biodegradable biomimetic macroporous hydrogel scaffold for bone tissue engineering.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Synthesis of an injectable biodegradable biomimetic macroporous hydrogel scaffold for bone tissue engineering./
Author:	Behravesh, Esfandiar.
Description:	192 p.
Notes:	Source: Dissertation Abstracts International, Volume: 64-05, Section: B, page: 2282.
Contained By:	Dissertation Abstracts International64-05B.
Subject:	Engineering, Biomedical. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3090126

Synthesis of an injectable biodegradable biomimetic macroporous hydrogel scaffold for bone tissue engineering.
Behravesh, Esfandiar.

Synthesis of an injectable biodegradable biomimetic macroporous hydrogel scaffold for bone tissue engineering. - 192 p.

Source: Dissertation Abstracts International, Volume: 64-05, Section: B, page: 2282.

Thesis (Ph.D.)--Rice University, 2003.

The objective of this work was to direct cell-biomaterial interaction by utilizing materials that reduce non-specific cell adhesion and covalently modify them with a cell adhesive peptide sequence to promote cell adhesion by a specific receptor-ligand interaction. The potential of poly(propylene fumarate-<italic>co</italic>-ethylene glycol) (P(PF-<italic>co</italic>-EG)) based hydrogels as biomimetic materials for controlling osteoblastic cell interaction and modulating cell response was examined.Subjects--Topical Terms:

1017684
Engineering, Biomedical.

Synthesis of an injectable biodegradable biomimetic macroporous hydrogel scaffold for bone tissue engineering.
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035 $a (UnM)AAI3090126
035 $a AAI3090126
040 $a UnM $c UnM
100 1 $a Behravesh, Esfandiar. $3 1946626
245 1 0 $a Synthesis of an injectable biodegradable biomimetic macroporous hydrogel scaffold for bone tissue engineering.
300 $a 192 p.
500 $a Source: Dissertation Abstracts International, Volume: 64-05, Section: B, page: 2282.
500 $a Adviser: Antonios G. Mikos.
502 $a Thesis (Ph.D.)--Rice University, 2003.
520 $a The objective of this work was to direct cell-biomaterial interaction by utilizing materials that reduce non-specific cell adhesion and covalently modify them with a cell adhesive peptide sequence to promote cell adhesion by a specific receptor-ligand interaction. The potential of poly(propylene fumarate-<italic>co</italic>-ethylene glycol) (P(PF-<italic>co</italic>-EG)) based hydrogels as biomimetic materials for controlling osteoblastic cell interaction and modulating cell response was examined.
520 $a First, the block copolymer P(PF-<italic>co</italic>-EG) was synthesized by transesterification of the homopolymers poly(propylene fumarate) and methoxy poly(ethylene glycol) to result in a block copolymer with terminal poly(ethylene glycol) (PEG) blocks. The effect of the PEG block length on the thermoreversible properties of the copolymer in water was examined. Next, P(PF-<italic>co</italic>-EG)-based hydrogels were crosslinked to thin films. Increasing the PEG block length of P(PF-<italic>co</italic>-EG) reduced marrow stromal osteoblast adhesion. Hydrogels were bulk-modified with an RGDS ligand attached to the backbone of the hydrogel with a PEG spacer arm. Marrow stromal osteoblast adhesion and migration was found to be dependent on the bulk concentration of RGDS peptide. In addition, the availability of the RGDS peptide at the surface of the bulk-modified hydrogels was dependent on the ratio of the PEG block length of P(PF-<italic>co</italic>-EG) and the PEG spacer arm linking the peptide to the hydrogel. A model biotin ligand was utilized to quantify the surface concentration of biotin bulk-modified hydrogels using an enzyme linked immunosorbent assay.
520 $a Macroporous hydrogels based on P(PF-<italic>co</italic>-EG) were synthesized by the same free-radical crosslinking approach as the thin film with potential for <italic>in situ</italic> formation. The effects of the free-radical initiation system and the carbon dioxide porogen precursor on the extent of crosslinking and morphology of the resulting macroporous hydrogel were examined. Moreover, these macroporous hydrogels were found to degrade hydrolytically in a bulk fashion with a decrease in material properties and dry weight, and no significant difference in porosity of the hydrogels. Degradation was dependent on the crosslinking density of the hydrogel. Finally, marrow stromal cells showed markers typical of differentiation to the osteoblastic phenotype when cultured for 28 days under conditions to promote their osteoblastic phenotype on RGDS-modified biomimetic macroporous hydrogels.
590 $a School code: 0187.
650 4 $a Engineering, Biomedical. $3 1017684
650 4 $a Biology, Cell. $3 1017686
650 4 $a Chemistry, Polymer. $3 1018428
690 $a 0541
690 $a 0379
690 $a 0495
710 2 0 $a Rice University. $3 960124
773 0 $t Dissertation Abstracts International $g 64-05B.
790 1 0 $a Mikos, Antonios G., $e advisor
790 $a 0187
791 $a Ph.D.
792 $a 2003
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3090126