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Antigenic similarities between a hum...

Ellison, Matthew Lee.

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Antigenic similarities between a human immunodeficiency virus envelope protein and several human immunoglobulins (Immune deficiency).

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Antigenic similarities between a human immunodeficiency virus envelope protein and several human immunoglobulins (Immune deficiency)./
作者:	Ellison, Matthew Lee.
面頁冊數:	50 p.
附註:	Source: Masters Abstracts International, Volume: 42-01, page: 0167.
Contained By:	Masters Abstracts International42-01.
標題:	Biology, Microbiology. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1414585

Antigenic similarities between a human immunodeficiency virus envelope protein and several human immunoglobulins (Immune deficiency).
Ellison, Matthew Lee.

Antigenic similarities between a human immunodeficiency virus envelope protein and several human immunoglobulins (Immune deficiency). - 50 p.

Source: Masters Abstracts International, Volume: 42-01, page: 0167.

Thesis (M.S.)--Mississippi State University, 2003.

Human Immunodeficiency Virus 1 (HIV-1) utilizes the envelope protein gp120 to bind host cells and leads to the establishment of infection. Recent studies have shown that simian gp120 may have epitopes that are similar to epitopes in the variable region of some human immunoglobulins idiotypes. This similarity may allow the virus to evade the immune response and, as antibodies are produced against the virus, may lead to the development of autoreactive anti-idiotype antibodies.Subjects--Topical Terms:

1017734
Biology, Microbiology.

Antigenic similarities between a human immunodeficiency virus envelope protein and several human immunoglobulins (Immune deficiency).
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100 1 $a Ellison, Matthew Lee. $3 1945928
245 1 0 $a Antigenic similarities between a human immunodeficiency virus envelope protein and several human immunoglobulins (Immune deficiency).
300 $a 50 p.
500 $a Source: Masters Abstracts International, Volume: 42-01, page: 0167.
500 $a Major Professor: George V. Pinchuk.
502 $a Thesis (M.S.)--Mississippi State University, 2003.
520 $a Human Immunodeficiency Virus 1 (HIV-1) utilizes the envelope protein gp120 to bind host cells and leads to the establishment of infection. Recent studies have shown that simian gp120 may have epitopes that are similar to epitopes in the variable region of some human immunoglobulins idiotypes. This similarity may allow the virus to evade the immune response and, as antibodies are produced against the virus, may lead to the development of autoreactive anti-idiotype antibodies.
520 $a To expand these observations on HIV-1gp120, twenty-one anti-HIV-1 gp120 antibodies were screened to determine their ability to cross-react with four human immunoglobulins. The antibodies 257-DIV and F425-B4a1 appeared to cross-react with a human immunoglobulin PAMLN6, but not with other human immunoglobulins. This study indicates that HIV-1 gp120 does present epitopes that are similar to some human immunoglobulins and that the potential exists for the development of autoreactive antiidiotype antibodies during the course of HIV infection.
590 $a School code: 0132.
650 4 $a Biology, Microbiology. $3 1017734
650 4 $a Chemistry, Biochemistry. $3 1017722
690 $a 0410
690 $a 0487
710 2 0 $a Mississippi State University. $3 1017550
773 0 $t Masters Abstracts International $g 42-01.
790 1 0 $a Pinchuk, George V., $e advisor
790 $a 0132
791 $a M.S.
792 $a 2003
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1414585