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Studies in antibody catalysis: I. Pr...

McDunn, Jonathan Edward.

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Studies in antibody catalysis: I. Preparation and evaluation of an insulin prodrug. II. Physiological roles for the antibody-catalyzed oxidation of water.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Studies in antibody catalysis: I. Preparation and evaluation of an insulin prodrug. II. Physiological roles for the antibody-catalyzed oxidation of water./
作者:	McDunn, Jonathan Edward.
面頁冊數:	148 p.
附註:	Source: Dissertation Abstracts International, Volume: 64-03, Section: B, page: 1231.
Contained By:	Dissertation Abstracts International64-03B.
標題:	Chemistry, Biochemistry. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3083908

Studies in antibody catalysis: I. Preparation and evaluation of an insulin prodrug. II. Physiological roles for the antibody-catalyzed oxidation of water.
McDunn, Jonathan Edward.

Studies in antibody catalysis: I. Preparation and evaluation of an insulin prodrug. II. Physiological roles for the antibody-catalyzed oxidation of water. - 148 p.

Source: Dissertation Abstracts International, Volume: 64-03, Section: B, page: 1231.

Thesis (Ph.D.)--The Scripps Research Institute, 2003.

The work described in this thesis investigates the catalytic ability of antibody molecules. In the first chapter, work is presented that demonstrates an application of a tailor-made catalytic antibody for the treatment of a metabolic deficiency. Specifically, insulin deactivation/reactivation is demonstrated as the basis for a novel insulin delivery system for the maintenance of basal blood glucose in the treatment of diabetes mellitus. In the second chapter, work is presented that explores the catalytic oxidation potential of all antibodies. This chemistry, along with what is known about the chemistry of the phagosome, suggests that antibodies can participate chemically in the destruction of foreign particles. This process is explored and characterized in the killing of Gram-negative bacteria, including pathogenic <italic>E. coli</italic> and <italic> S. typhimurium</italic>. Finally, the third chapter extends the studies on antibody-mediated oxidation to the subject of inflammatory disease. Specifically, the question as to whether antibody-mediated oxidation occurs and whether it has any effect on the progression of tissue damage during ischemia/reperfusion injury as modeled by the Langendorff method is investigated.Subjects--Topical Terms:

1017722
Chemistry, Biochemistry.

Studies in antibody catalysis: I. Preparation and evaluation of an insulin prodrug. II. Physiological roles for the antibody-catalyzed oxidation of water.
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