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Bioavailability studies of folate in...

Garbis, Spiros D.

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Bioavailability studies of folate in humans.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Bioavailability studies of folate in humans./
作者:	Garbis, Spiros D.
面頁冊數:	176 p.
附註:	Source: Dissertation Abstracts International, Volume: 64-07, Section: B, page: 3196.
Contained By:	Dissertation Abstracts International64-07B.
標題:	Health Sciences, Nutrition. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3098353

Bioavailability studies of folate in humans.
Garbis, Spiros D.

Bioavailability studies of folate in humans. - 176 p.

Source: Dissertation Abstracts International, Volume: 64-07, Section: B, page: 3196.

Thesis (Ph.D.)--University of Illinois at Chicago, Health Sciences Center, 2003.

Folate deficiency can cause the onset of various chronic disease states. The assumed bioavailability of folates derived plant foods is approximately 50–80% compared to synthetic folic acid used in multi-vitamin preparations and fortification of foods. A possible reason for this difference in bioavailability may be the deconjugation of the polyglutamate chain of food folates necessary for their absorption. Current knowledge, however, remains inconclusive on folate bioavailability due to limitations clinical designs and inefficient analytical methodology.Subjects--Topical Terms:

1017801
Health Sciences, Nutrition.

Bioavailability studies of folate in humans.
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500 $a Source: Dissertation Abstracts International, Volume: 64-07, Section: B, page: 3196.
500 $a Adviser: Richard B. van Breemen.
502 $a Thesis (Ph.D.)--University of Illinois at Chicago, Health Sciences Center, 2003.
520 $a Folate deficiency can cause the onset of various chronic disease states. The assumed bioavailability of folates derived plant foods is approximately 50–80% compared to synthetic folic acid used in multi-vitamin preparations and fortification of foods. A possible reason for this difference in bioavailability may be the deconjugation of the polyglutamate chain of food folates necessary for their absorption. Current knowledge, however, remains inconclusive on folate bioavailability due to limitations clinical designs and inefficient analytical methodology.
520 $a The primary objectives of this dissertation is to develop and implement a novel and effective LC-MS-MS based analytical methodology combined with the use of differentially <super>13</super>C-labeled folates for the execution of <italic>in vivo</italic> long-term clinical protocols based on the chronic oral administration at sub-physiologic doses in healthy human subjects and of <italic>in vitro</italic> Caco-2 cell monolayer assay experiments in order to discriminate their bioavailability and biotransformation phenomena from the endogenous ones.
520 $a The main results from these studies show that the in vivo relative bioavailability of folic acid is &sim;30% greater than that of folic acid hexaglutamate in terms of resulting plasma 5-CH3-H4folate levels. However, the <italic>in vivo</italic> relative bioavailability of folic acid is &sim;40% smaller than that of folic acid hexaglutamate in terms of resulting plasma 5-HCO-H4folate levels. The <italic>in vitro</italic> Caco-2 cell monolayer experiments showed that the natural occurring folates in foods exhibited carrier mediated, facilitated transport whereas the synthetic folic acid exhibited passive diffusion transport across the epithelial cell monolayer barrier. Also, these experiments provided evidence for extensive metabolism of both folic acid and folic acid hexaglutamate.
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