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Interactive effects of aerobic and r...

Carrithers, John Allen.

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Interactive effects of aerobic and resistance exercise on muscle protein synthesis.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Interactive effects of aerobic and resistance exercise on muscle protein synthesis./
Author:	Carrithers, John Allen.
Description:	124 p.
Notes:	Source: Dissertation Abstracts International, Volume: 64-04, Section: B, page: 1571.
Contained By:	Dissertation Abstracts International64-04B.
Subject:	Biology, Animal Physiology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3088594

Interactive effects of aerobic and resistance exercise on muscle protein synthesis.
Carrithers, John Allen.

Interactive effects of aerobic and resistance exercise on muscle protein synthesis. - 124 p.

Source: Dissertation Abstracts International, Volume: 64-04, Section: B, page: 1571.

Thesis (Ph.D.)--University of Arkansas for Medical Sciences, 2003.

Aerobic training performed in conjunction with resistance training has been shown to have an interfering effect on increasing skeletal muscle size and strength. It has also been shown that amino acid availability in the post-absorptive state limits the postexercise increase in muscle protein synthesis. Under these circumstances the different protein fractions of the muscle may compete for amino acids depending on the exercise stimulus. As a result of the aerobic exercise component of concurrent training, mitochondrial protein synthesis may compete for amino acids and limit the amino acids available for myofibrillar protein synthesis, which may ultimately lead to the attenuated muscle size and strength increases noted with concurrent training. This study examined whether alterations in postexercise muscle protein metabolism could explain the interfering effect of aerobic exercise (AE) on resistance exercise (RE). Twelve young moderately active men (<italic>n</italic> = 6) and women (<italic> n</italic> = 6), 26 ± 2y, underwent a bout of RE with one leg and a bout of AE + RE with the other leg, coupled with an infusion of [<super>2</super>H<sub>5</sub>]phenylalanine and muscle biopsies to determine mixed, myofibrillar, mitochondrial, and sarcoplasmic muscle protein synthesis rates (%/hr) in the post-absorptive state. AE consisted of a 90-minute exercise session on a one-legged cycle ergometer at 60% of peak power. RE was completed with leg press and leg extension exercises, each consisting of 3 sets of 10 repetitions with a fourth set to failure, all at 80% of one repetition maximum. AE + RE decreased muscle glycogen content by 327 ± 33mmol/kg dry wt.; whereas, RE decreased muscle glycogen content by 93 ± 26mmol/kg dry wt (p < 0.05). No differences were found for mixed (AE + RE: 0.076 ± 0.005 vs. RE: 0.074 ± 0.004%/hr), myofibrillar (AE + RE: 0.100 ± 0.007 vs. RE: 0.092 ± 0.019%/hr), mitochondrial (AE + RE: 0.109 ± 0.024 vs. RE: 0.099 ± 0.014%/hr), or sarcoplasmic (AE + RE: 0.108 ± 0.008vs. RE: 0.092 ± 0.014%/hr) protein synthesis rates between the AE + RE and the RE leg. These results suggest that the acute changes in post-absorptive general muscle protein synthesis and synthesis within selected muscle subfractions cannot account for the limited muscle mass and strength gains imposed by concurrent aerobic and resistance exercise.Subjects--Topical Terms:

1017835
Biology, Animal Physiology.

Interactive effects of aerobic and resistance exercise on muscle protein synthesis.
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035 $a (UnM)AAI3088594
035 $a AAI3088594
040 $a UnM $c UnM
100 1 $a Carrithers, John Allen. $3 1945275
245 1 0 $a Interactive effects of aerobic and resistance exercise on muscle protein synthesis.
300 $a 124 p.
500 $a Source: Dissertation Abstracts International, Volume: 64-04, Section: B, page: 1571.
500 $a Adviser: Todd Trappe.
502 $a Thesis (Ph.D.)--University of Arkansas for Medical Sciences, 2003.
520 $a Aerobic training performed in conjunction with resistance training has been shown to have an interfering effect on increasing skeletal muscle size and strength. It has also been shown that amino acid availability in the post-absorptive state limits the postexercise increase in muscle protein synthesis. Under these circumstances the different protein fractions of the muscle may compete for amino acids depending on the exercise stimulus. As a result of the aerobic exercise component of concurrent training, mitochondrial protein synthesis may compete for amino acids and limit the amino acids available for myofibrillar protein synthesis, which may ultimately lead to the attenuated muscle size and strength increases noted with concurrent training. This study examined whether alterations in postexercise muscle protein metabolism could explain the interfering effect of aerobic exercise (AE) on resistance exercise (RE). Twelve young moderately active men (<italic>n</italic> = 6) and women (<italic> n</italic> = 6), 26 ± 2y, underwent a bout of RE with one leg and a bout of AE + RE with the other leg, coupled with an infusion of [<super>2</super>H<sub>5</sub>]phenylalanine and muscle biopsies to determine mixed, myofibrillar, mitochondrial, and sarcoplasmic muscle protein synthesis rates (%/hr) in the post-absorptive state. AE consisted of a 90-minute exercise session on a one-legged cycle ergometer at 60% of peak power. RE was completed with leg press and leg extension exercises, each consisting of 3 sets of 10 repetitions with a fourth set to failure, all at 80% of one repetition maximum. AE + RE decreased muscle glycogen content by 327 ± 33mmol/kg dry wt.; whereas, RE decreased muscle glycogen content by 93 ± 26mmol/kg dry wt (p < 0.05). No differences were found for mixed (AE + RE: 0.076 ± 0.005 vs. RE: 0.074 ± 0.004%/hr), myofibrillar (AE + RE: 0.100 ± 0.007 vs. RE: 0.092 ± 0.019%/hr), mitochondrial (AE + RE: 0.109 ± 0.024 vs. RE: 0.099 ± 0.014%/hr), or sarcoplasmic (AE + RE: 0.108 ± 0.008vs. RE: 0.092 ± 0.014%/hr) protein synthesis rates between the AE + RE and the RE leg. These results suggest that the acute changes in post-absorptive general muscle protein synthesis and synthesis within selected muscle subfractions cannot account for the limited muscle mass and strength gains imposed by concurrent aerobic and resistance exercise.
590 $a School code: 0365.
650 4 $a Biology, Animal Physiology. $3 1017835
650 4 $a Biophysics, General. $3 1019105
650 4 $a Health Sciences, Recreation. $3 1018003
690 $a 0433
690 $a 0786
690 $a 0575
710 2 0 $a University of Arkansas for Medical Sciences. $3 1021816
773 0 $t Dissertation Abstracts International $g 64-04B.
790 1 0 $a Trappe, Todd, $e advisor
790 $a 0365
791 $a Ph.D.
792 $a 2003
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3088594