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Structural and functional implicatio...

Fernandez-Seara, Maria Asuncion.

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Structural and functional implications of bone water and mineral density studied by NMR.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Structural and functional implications of bone water and mineral density studied by NMR./
作者:	Fernandez-Seara, Maria Asuncion.
面頁冊數:	110 p.
附註:	Source: Dissertation Abstracts International, Volume: 64-04, Section: B, page: 1652.
Contained By:	Dissertation Abstracts International64-04B.
標題:	Biophysics, Medical. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3087399

Structural and functional implications of bone water and mineral density studied by NMR.
Fernandez-Seara, Maria Asuncion.

Structural and functional implications of bone water and mineral density studied by NMR. - 110 p.

Source: Dissertation Abstracts International, Volume: 64-04, Section: B, page: 1652.

Thesis (Ph.D.)--University of Pennsylvania, 2003.

The degree of mineralization of bone is an important parameter determining bone mechanical competence. However, the importance of bone composition has been often ignored by assuming that it is not altered in common bone diseases such as osteoporosis. This is due in part to the lack of a non-invasive method for probing bone composition <italic>in vivo</italic>. The objective of this dissertation research was to evaluate the hypothesis that the mineralization state of the matrix can be assessed indirectly by measuring the osteoid water content. Specifically, a non-destructive NMR technique for water quantification <italic> in vitro</italic> was developed. Further, changes in water content in an animal model of osteomalacia were studied and it was shown how these changes relate to variations in mineral content. Strong evidence is presented to support the hypothesis that water content is related to bone mechanical properties and that this parameter can potentially be used as a predictor of bone strength. The transport properties of osteiod water in the calcified matrix and the relation to bone microstructure were also studied and two different water fractions were identified in cortical bone. Finally, a NMR pulse sequence was developed to image semi-solid materials and the potential of the sequence for imaging of bone <italic>ex vivo</italic> was demonstrated. The research presented in this dissertation represents a step toward the development of a technique for probing bone composition <italic>in vivo</italic>.Subjects--Topical Terms:

1017681
Biophysics, Medical.

Structural and functional implications of bone water and mineral density studied by NMR.
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245 1 0 $a Structural and functional implications of bone water and mineral density studied by NMR.
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500 $a Source: Dissertation Abstracts International, Volume: 64-04, Section: B, page: 1652.
500 $a Adviser: Felix W. Wehrli.
502 $a Thesis (Ph.D.)--University of Pennsylvania, 2003.
520 $a The degree of mineralization of bone is an important parameter determining bone mechanical competence. However, the importance of bone composition has been often ignored by assuming that it is not altered in common bone diseases such as osteoporosis. This is due in part to the lack of a non-invasive method for probing bone composition <italic>in vivo</italic>. The objective of this dissertation research was to evaluate the hypothesis that the mineralization state of the matrix can be assessed indirectly by measuring the osteoid water content. Specifically, a non-destructive NMR technique for water quantification <italic> in vitro</italic> was developed. Further, changes in water content in an animal model of osteomalacia were studied and it was shown how these changes relate to variations in mineral content. Strong evidence is presented to support the hypothesis that water content is related to bone mechanical properties and that this parameter can potentially be used as a predictor of bone strength. The transport properties of osteiod water in the calcified matrix and the relation to bone microstructure were also studied and two different water fractions were identified in cortical bone. Finally, a NMR pulse sequence was developed to image semi-solid materials and the potential of the sequence for imaging of bone <italic>ex vivo</italic> was demonstrated. The research presented in this dissertation represents a step toward the development of a technique for probing bone composition <italic>in vivo</italic>.
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650 4 $a Engineering, Biomedical. $3 1017684
650 4 $a Biology, Cell. $3 1017686
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710 2 0 $a University of Pennsylvania. $3 1017401
773 0 $t Dissertation Abstracts International $g 64-04B.
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