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Simulation of fracture healing media...

Bailon-Plaza Alicia.

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Simulation of fracture healing mediated by growth factors and mechanical stimulus.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Simulation of fracture healing mediated by growth factors and mechanical stimulus./
Author:	Bailon-Plaza Alicia.
Description:	220 p.
Notes:	Source: Dissertation Abstracts International, Volume: 64-04, Section: B, page: 1809.
Contained By:	Dissertation Abstracts International64-04B.
Subject:	Engineering, Biomedical. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3087035

Simulation of fracture healing mediated by growth factors and mechanical stimulus.
Bailon-Plaza Alicia.

Simulation of fracture healing mediated by growth factors and mechanical stimulus. - 220 p.

Source: Dissertation Abstracts International, Volume: 64-04, Section: B, page: 1809.

Thesis (Ph.D.)--Cornell University, 2003.

Fracture healing constitutes a unique opportunity to investigate bone regeneration in a localized and experimentally controllable environment. Moreover, fractures constitute 30% of the 3 million annual musculoskeletal hospitalizations in the United States, and 10% of the 6 million annual fractures present signs of impaired or delayed healing, requiring open orthopaedic intervention (Praemer <italic> et al.</italic>, 1999). Understanding normal and pathological healing, and designing clinical strategies for the latter cases, are critical topics of research. <italic>In vivo</italic> animal experiments have demonstrated the potent role of growth factors and mechanical stimuli in directing cell and tissue activity during fracture healing. In particular, experiments have shown the alterations in the cellular and healing activity resulting from modified growth factor production in transgenic or knockout animals, directed injections of growth factors, or variations in the mechanical stability of the callus. Although these experiments have been invaluable for understanding the in vivo effects of a modest number of perturbations to individual factors, understanding multiple perturbations becomes unfeasible experimentally. In these cases the development of sophisticated mathematical models becomes critical.Subjects--Topical Terms:

1017684
Engineering, Biomedical.

Simulation of fracture healing mediated by growth factors and mechanical stimulus.
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100 1 $a Bailon-Plaza Alicia. $3 1945267
245 1 0 $a Simulation of fracture healing mediated by growth factors and mechanical stimulus.
300 $a 220 p.
500 $a Source: Dissertation Abstracts International, Volume: 64-04, Section: B, page: 1809.
500 $a Adviser: Marjolein C. H. Van Der Meulen.
502 $a Thesis (Ph.D.)--Cornell University, 2003.
520 $a Fracture healing constitutes a unique opportunity to investigate bone regeneration in a localized and experimentally controllable environment. Moreover, fractures constitute 30% of the 3 million annual musculoskeletal hospitalizations in the United States, and 10% of the 6 million annual fractures present signs of impaired or delayed healing, requiring open orthopaedic intervention (Praemer <italic> et al.</italic>, 1999). Understanding normal and pathological healing, and designing clinical strategies for the latter cases, are critical topics of research. <italic>In vivo</italic> animal experiments have demonstrated the potent role of growth factors and mechanical stimuli in directing cell and tissue activity during fracture healing. In particular, experiments have shown the alterations in the cellular and healing activity resulting from modified growth factor production in transgenic or knockout animals, directed injections of growth factors, or variations in the mechanical stability of the callus. Although these experiments have been invaluable for understanding the in vivo effects of a modest number of perturbations to individual factors, understanding multiple perturbations becomes unfeasible experimentally. In these cases the development of sophisticated mathematical models becomes critical.
520 $a In this thesis, a mathematical framework was developed to investigate in a controlled fashion the effects of growth factors and mechanical stimuli on bone repair. The model was calibrated and validated based on animal experiments from the literature. Among the indicators of cell, tissue and growth factor activity examined, the rate of osteogenic growth factor production and the duration of initial release of growth factors upon injury were found to be particularly important parameters for complete ossification and successful healing. Furthermore taking into account the role of mechanical stimuli on cell activity was shown to be essential for accurately predicting the ossification patterns in the callus. Finally, simulations of sheep fractures demonstrated the importance of early moderate mechanical stimulation of rigidly fixed calluses; the advantages of using relatively less rigid fixators, and the adversary effects of excessive loading. This model of fracture healing is the first to consider cell, tissue and growth factor activity, in addition to mechanical stimuli, in a temporal context, and provides a mathematical framework with which to design experiments and understand pathological conditions.
590 $a School code: 0058.
650 4 $a Engineering, Biomedical. $3 1017684
650 4 $a Engineering, Mechanical. $3 783786
650 4 $a Health Sciences, Rehabilitation and Therapy. $3 1017926
650 4 $a Health Sciences, Medicine and Surgery. $3 1017756
650 4 $a Biophysics, Medical. $3 1017681
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710 2 0 $a Cornell University. $3 530586
773 0 $t Dissertation Abstracts International $g 64-04B.
790 1 0 $a Van Der Meulen, Marjolein C. H., $e advisor
790 $a 0058
791 $a Ph.D.
792 $a 2003
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3087035