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Genetic studies of RNA-mediated DNA ...
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Liu, Yifan.
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Genetic studies of RNA-mediated DNA elimination in the developing macronuclei of Tetrahymena thermophila.
紀錄類型:
書目-電子資源 : Monograph/item
正題名/作者:
Genetic studies of RNA-mediated DNA elimination in the developing macronuclei of Tetrahymena thermophila./
作者:
Liu, Yifan.
面頁冊數:
219 p.
附註:
Source: Dissertation Abstracts International, Volume: 64-08, Section: B, page: 3647.
電子資源:
http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3102284
Genetic studies of RNA-mediated DNA elimination in the developing macronuclei of Tetrahymena thermophila.
Liu, Yifan.
Genetic studies of RNA-mediated DNA elimination in the developing macronuclei of Tetrahymena thermophila.
- 219 p.
Source: Dissertation Abstracts International, Volume: 64-08, Section: B, page: 3647.
Thesis (Ph.D.)--The University of Rochester, 2003.
Post-translational modification of histones is a highly conserved mechanism for modulating the dynamic structure of chromatin and is involved in transcription regulation. Histone H3 lysine 9 methylation is a hallmark of heterochromatin formation and gene silencing in a wide range of eukaryotes. In <italic>Tetrahymena </italic>, this modification and heterochromatin formation occur exclusively in the developing macronuclei, in association with the DNA sequences targeted for deletion. RNA-mediated gene silencing has recently been implicated in the initial targeting of H3 lysine 9 methylation and heterochromatin formation in <italic>S. pombe</italic>, as well as in the developmentally regulated DNA elimination in <italic>Tetrahymena</italic>.
Genetic studies of RNA-mediated DNA elimination in the developing macronuclei of Tetrahymena thermophila.
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Genetic studies of RNA-mediated DNA elimination in the developing macronuclei of Tetrahymena thermophila.
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219 p.
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Source: Dissertation Abstracts International, Volume: 64-08, Section: B, page: 3647.
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Supervisor: Martin A. Gorovsky.
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Thesis (Ph.D.)--The University of Rochester, 2003.
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Post-translational modification of histones is a highly conserved mechanism for modulating the dynamic structure of chromatin and is involved in transcription regulation. Histone H3 lysine 9 methylation is a hallmark of heterochromatin formation and gene silencing in a wide range of eukaryotes. In <italic>Tetrahymena </italic>, this modification and heterochromatin formation occur exclusively in the developing macronuclei, in association with the DNA sequences targeted for deletion. RNA-mediated gene silencing has recently been implicated in the initial targeting of H3 lysine 9 methylation and heterochromatin formation in <italic>S. pombe</italic>, as well as in the developmentally regulated DNA elimination in <italic>Tetrahymena</italic>.
520
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Genetic studies were conducted to further understand the mechanism of DNA elimination in <italic>Tetrahymena</italic>. Mutating the lysine 9 residue in H3 prevents its methylation and disrupts DNA elimination, but does not affect the accumulation of small RNAs. Knocking out the <italic>TWI1</italic> gene, which is required for the accumulation of small RNAs and DNA elimination, also abolishes H3 lysine 9 methylation. This indicates that small RNA generation is upstream of H3 lysine 9 methylation, which is in turn required for DNA elimination in <italic>Tetrahymena</italic>
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http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3102284
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