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Synthesis of novel chiral dipyridylp...

Wu, Jing.

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Synthesis of novel chiral dipyridylphosphine ligands and their application in catalytic asymmetric hydrogenation reactions.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Synthesis of novel chiral dipyridylphosphine ligands and their application in catalytic asymmetric hydrogenation reactions./
Author:	Wu, Jing.
Description:	354 p.
Notes:	Source: Dissertation Abstracts International, Volume: 64-02, Section: B, page: 0723.
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3082856

Synthesis of novel chiral dipyridylphosphine ligands and their application in catalytic asymmetric hydrogenation reactions.
Wu, Jing.

Synthesis of novel chiral dipyridylphosphine ligands and their application in catalytic asymmetric hydrogenation reactions. - 354 p.

Source: Dissertation Abstracts International, Volume: 64-02, Section: B, page: 0723.

Thesis (Ph.D.)--Hong Kong Polytechnic (People's Republic of China), 2003.

We have recently developed a chiral dipyridylphosphine ligand 2,2<super> ′</super>,6,6<super>′</super>-tetramethoxy-4,4<super>′</super>-bis(diphenylphosphino)-3,3<super> ′</super>-bipyridine (P-Phos), which was found to be very effective in the Ru-catalyzed asymmetric hydrogenation of 2-(6<super>′</super>-methoxy-2<super> ′</super>-naphthyl)propenoic acid to give the nonsteroidal anti-inflammatory drug naproxen.

Synthesis of novel chiral dipyridylphosphine ligands and their application in catalytic asymmetric hydrogenation reactions.
LDR:02112nmm 2200181 4500 001 1853861
005 20040517094428.5
008 130614s2003 eng d
035 $a (UnM)AAI3082856
035 $a AAI3082856
040 $a UnM $c UnM
100 1 $a Wu, Jing. $3 1001228
245 1 0 $a Synthesis of novel chiral dipyridylphosphine ligands and their application in catalytic asymmetric hydrogenation reactions.
300 $a 354 p.
500 $a Source: Dissertation Abstracts International, Volume: 64-02, Section: B, page: 0723.
500 $a Supervisors: C.-H. Yeung; Albert S. C. Chan.
502 $a Thesis (Ph.D.)--Hong Kong Polytechnic (People's Republic of China), 2003.
520 $a We have recently developed a chiral dipyridylphosphine ligand 2,2<super> ′</super>,6,6<super>′</super>-tetramethoxy-4,4<super>′</super>-bis(diphenylphosphino)-3,3<super> ′</super>-bipyridine (P-Phos), which was found to be very effective in the Ru-catalyzed asymmetric hydrogenation of 2-(6<super>′</super>-methoxy-2<super> ′</super>-naphthyl)propenoic acid to give the nonsteroidal anti-inflammatory drug naproxen.
520 $a In this study, we have designed and prepared two analogs of P-Phos, 2,2<super> ′</super>,6,6<super>′</super>-tetramethoxy-4,4<super>′</super>-bis[di(<italic> p</italic>-methyl-phenyl)phosphino]-3,3<super>′</super>-bipyridine (Tol-P-Phos) 2,2<super>′</super>,6,6<super>′</super>-tetramethoxy-4,4<super> ′</super>-bis[di-(3,5-dimethylphenyl)phosphino]-3,3<super>′</super>-bipyridine (Xyl-P-Phos) by introducing various substituents onto the four phenyl rings in P-Phos to tune its electronic and steric properties. In addition, we also designed type of P-Phos variant, 2,2<super>′</super>,6,6<super>′ </super>-tetramethoxy-4,4<super>′</super>-bis(dicyclohexylphosphino)-3,3<super> ′</super>-bipyridine (Cy-P-Phos), which bears four bulky, electron-donating cyclohexyl groups in the two phosphorus atoms, instead of the four arene groups of conventional P-Phos ligands
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3082856