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The ecology of colicins.
~
Kirkup, Benjamin C., Jr.
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The ecology of colicins.
紀錄類型:
書目-電子資源 : Monograph/item
正題名/作者:
The ecology of colicins./
作者:
Kirkup, Benjamin C., Jr.
面頁冊數:
200 p.
附註:
Source: Dissertation Abstracts International, Volume: 65-03, Section: B, page: 1123.
Contained By:
Dissertation Abstracts International65-03B.
標題:
Biology, Ecology. -
電子資源:
http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3125228
ISBN:
0496725181
The ecology of colicins.
Kirkup, Benjamin C., Jr.
The ecology of colicins.
- 200 p.
Source: Dissertation Abstracts International, Volume: 65-03, Section: B, page: 1123.
Thesis (Ph.D.)--Yale University, 2004.
Colicins, specific and highly potent toxins, have been presumed to serve the Escherichia coli that produce them in mediating population-level and/or community level interactions in the wild. Prior attempts to assess the role of colicins have found them to play a significant role in invasion or defense of laboratory environments, but have failed to show a reproducible effect under more natural settings. The goal of this research is to incorporate mathematical and experimental methods to permit studies of the ecology of colicins in vivo. These methods include the use of strains of E. coli that are isogenic save for the production of, resistance or sensitivity to one of two colicins. These strains were studied with both in vitro and in vivo methods. Most compelling, experiments in mice reveal that colicins are effective antagonistic agents and that a trio of strains, including a sensitive, a producer, and a resistant strain, forms a non-transitive system recognizable as the rock-paper-scissors model from game theory. In theory, the non-transitive structure of this trio leads to cycling among the strains. This cycle was observed in vivo .
ISBN: 0496725181Subjects--Topical Terms:
1017726
Biology, Ecology.
The ecology of colicins.
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Colicins, specific and highly potent toxins, have been presumed to serve the Escherichia coli that produce them in mediating population-level and/or community level interactions in the wild. Prior attempts to assess the role of colicins have found them to play a significant role in invasion or defense of laboratory environments, but have failed to show a reproducible effect under more natural settings. The goal of this research is to incorporate mathematical and experimental methods to permit studies of the ecology of colicins in vivo. These methods include the use of strains of E. coli that are isogenic save for the production of, resistance or sensitivity to one of two colicins. These strains were studied with both in vitro and in vivo methods. Most compelling, experiments in mice reveal that colicins are effective antagonistic agents and that a trio of strains, including a sensitive, a producer, and a resistant strain, forms a non-transitive system recognizable as the rock-paper-scissors model from game theory. In theory, the non-transitive structure of this trio leads to cycling among the strains. This cycle was observed in vivo .
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