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Development and application of perfu...

Liu, Ho-Ling Anthony.

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Development and application of perfusion based functional MRI.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Development and application of perfusion based functional MRI./
作者:	Liu, Ho-Ling Anthony.
面頁冊數:	118 p.
附註:	Source: Dissertation Abstracts International, Volume: 61-04, Section: B, page: 1824.
Contained By:	Dissertation Abstracts International61-04B.
標題:	Biophysics, Medical. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=9957995
ISBN:	0599755024

Development and application of perfusion based functional MRI.
Liu, Ho-Ling Anthony.

Development and application of perfusion based functional MRI. - 118 p.

Source: Dissertation Abstracts International, Volume: 61-04, Section: B, page: 1824.

Thesis (Ph.D.)--The University of Texas Health Science Center at San Antonio, 2000.

Measurement of cerebral perfusion has widespread clinical and research applications. Recently, the development of novel magnetic resonance imaging techniques has enabled us to noninvasively measure perfusion. Compared with other modalities, perfusion MRI has the advantages of high spatial resolution, use of nonradioactive tracers, low cost and wide availability. However, the reliability of these techniques has not yet been previously optimized. In addition, the application of perfusion MRI needs to be widened by resolving some critical limitations, such as the presence of susceptibility artifacts and temporal resolution.

ISBN: 0599755024Subjects--Topical Terms:

1017681
Biophysics, Medical.

Development and application of perfusion based functional MRI.
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245 1 0 $a Development and application of perfusion based functional MRI.
300 $a 118 p.
500 $a Source: Dissertation Abstracts International, Volume: 61-04, Section: B, page: 1824.
500 $a Supervisor: Jia-Hong Gao.
502 $a Thesis (Ph.D.)--The University of Texas Health Science Center at San Antonio, 2000.
520 $a Measurement of cerebral perfusion has widespread clinical and research applications. Recently, the development of novel magnetic resonance imaging techniques has enabled us to noninvasively measure perfusion. Compared with other modalities, perfusion MRI has the advantages of high spatial resolution, use of nonradioactive tracers, low cost and wide availability. However, the reliability of these techniques has not yet been previously optimized. In addition, the application of perfusion MRI needs to be widened by resolving some critical limitations, such as the presence of susceptibility artifacts and temporal resolution.
520 $a Specific aim 1. To develop a reliable perfusion MRI technique using dynamic susceptibility imaging.
520 $a Dynamic susceptibility MRI has been recently developed as a promising technique for perfusion imaging. However, its use has not been previously optimized. In this specific aim, an improved technique utilizing a novel deconvolution method was proposed and evaluated.
520 $a Specific aim 2. To develop a perfusion MRI technique for detection of lesions at high susceptibility areas.
520 $a One of the major limitations to measure blood flow using dynamic susceptibility MRI is its failure in high susceptibility areas. In this specific aim, we proposed a perfusion technique with endogenous tracers, FAIR-HASTE, which is in principle insensitive to magnetic inhomogeneity. We applied this technique in a functional MRI study with visual stimulation and the diagnosis of the interictal hypoperfusion in partial complex epilepsy of temporal lobe origin.
520 $a Specific aim 3. To develop a perfusion MRI technique with high temporal resolution.
520 $a Event-related functional MRI based on blood oxygenation level-dependence (BOLD) contrast has been recently developed to study human brain activation in response to brief stimulation. While blood flow is a more direct measurement of hemodynamic response, perfusion based ER-fMRI may provide better localization of the brain activation as well as improve our understanding of underlying physiological mechanism. In this specific aim, we proposed a novel technique that can achieve a temporal resolution (1 sec) high enough to detect the transient perfusion response. The perfusion based ER-fMRI was compared to the BOLD based ER-fMRI. Perfusion response appeared to be very similar to BOLD response, however, reached the peak approximately 1 sec earlier.
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