東華大學圖書館 |

Language: English

Help

回圖書館首頁

手機版館藏查詢

Back

Switch To: Labeled | MARC Mode | ISBD

Development and application of perfu...

Liu, Ho-Ling Anthony.

Linked to FindBook

Google Book

Amazon

博客來

Development and application of perfusion based functional MRI.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Development and application of perfusion based functional MRI./
Author:	Liu, Ho-Ling Anthony.
Description:	118 p.
Notes:	Source: Dissertation Abstracts International, Volume: 61-04, Section: B, page: 1824.
Contained By:	Dissertation Abstracts International61-04B.
Subject:	Biophysics, Medical. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=9957995
ISBN:	0599755024

Development and application of perfusion based functional MRI.
Liu, Ho-Ling Anthony.

Development and application of perfusion based functional MRI. - 118 p.

Source: Dissertation Abstracts International, Volume: 61-04, Section: B, page: 1824.

Thesis (Ph.D.)--The University of Texas Health Science Center at San Antonio, 2000.

Measurement of cerebral perfusion has widespread clinical and research applications. Recently, the development of novel magnetic resonance imaging techniques has enabled us to noninvasively measure perfusion. Compared with other modalities, perfusion MRI has the advantages of high spatial resolution, use of nonradioactive tracers, low cost and wide availability. However, the reliability of these techniques has not yet been previously optimized. In addition, the application of perfusion MRI needs to be widened by resolving some critical limitations, such as the presence of susceptibility artifacts and temporal resolution.

ISBN: 0599755024Subjects--Topical Terms:

1017681
Biophysics, Medical.

Development and application of perfusion based functional MRI.
LDR:03425nmm 2200361 4500 001 1851517
005 20051216102009.5
008 130614s2000 eng d
020 $a 0599755024
035 $a (UnM)AAI9957995
035 $a AAI9957995
040 $a UnM $c UnM
100 1 $a Liu, Ho-Ling Anthony. $3 1939403
245 1 0 $a Development and application of perfusion based functional MRI.
300 $a 118 p.
500 $a Source: Dissertation Abstracts International, Volume: 61-04, Section: B, page: 1824.
500 $a Supervisor: Jia-Hong Gao.
502 $a Thesis (Ph.D.)--The University of Texas Health Science Center at San Antonio, 2000.
520 $a Measurement of cerebral perfusion has widespread clinical and research applications. Recently, the development of novel magnetic resonance imaging techniques has enabled us to noninvasively measure perfusion. Compared with other modalities, perfusion MRI has the advantages of high spatial resolution, use of nonradioactive tracers, low cost and wide availability. However, the reliability of these techniques has not yet been previously optimized. In addition, the application of perfusion MRI needs to be widened by resolving some critical limitations, such as the presence of susceptibility artifacts and temporal resolution.
520 $a Specific aim 1. To develop a reliable perfusion MRI technique using dynamic susceptibility imaging.
520 $a Dynamic susceptibility MRI has been recently developed as a promising technique for perfusion imaging. However, its use has not been previously optimized. In this specific aim, an improved technique utilizing a novel deconvolution method was proposed and evaluated.
520 $a Specific aim 2. To develop a perfusion MRI technique for detection of lesions at high susceptibility areas.
520 $a One of the major limitations to measure blood flow using dynamic susceptibility MRI is its failure in high susceptibility areas. In this specific aim, we proposed a perfusion technique with endogenous tracers, FAIR-HASTE, which is in principle insensitive to magnetic inhomogeneity. We applied this technique in a functional MRI study with visual stimulation and the diagnosis of the interictal hypoperfusion in partial complex epilepsy of temporal lobe origin.
520 $a Specific aim 3. To develop a perfusion MRI technique with high temporal resolution.
520 $a Event-related functional MRI based on blood oxygenation level-dependence (BOLD) contrast has been recently developed to study human brain activation in response to brief stimulation. While blood flow is a more direct measurement of hemodynamic response, perfusion based ER-fMRI may provide better localization of the brain activation as well as improve our understanding of underlying physiological mechanism. In this specific aim, we proposed a novel technique that can achieve a temporal resolution (1 sec) high enough to detect the transient perfusion response. The perfusion based ER-fMRI was compared to the BOLD based ER-fMRI. Perfusion response appeared to be very similar to BOLD response, however, reached the peak approximately 1 sec earlier.
590 $a School code: 0853.
650 4 $a Biophysics, Medical. $3 1017681
650 4 $a Health Sciences, Radiology. $3 1019076
650 4 $a Engineering, Biomedical. $3 1017684
690 $a 0760
690 $a 0574
690 $a 0541
710 2 0 $a The University of Texas Health Science Center at San Antonio. $3 1030926
773 0 $t Dissertation Abstracts International $g 61-04B.
790 1 0 $a Gao, Jia-Hong, $e advisor
790 $a 0853
791 $a Ph.D.
792 $a 2000
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=9957995