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Targeting Helicobacter pylori with a...

Marquette, Michael J.

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Targeting Helicobacter pylori with antibodies: Exploring drug delivery with polymer beads.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Targeting Helicobacter pylori with antibodies: Exploring drug delivery with polymer beads./
作者:	Marquette, Michael J.
面頁冊數:	98 p.
附註:	Source: Masters Abstracts International, Volume: 42-06, page: 2155.
Contained By:	Masters Abstracts International42-06.
標題:	Health Sciences, Immunology. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1420671
ISBN:	0496254197

Targeting Helicobacter pylori with antibodies: Exploring drug delivery with polymer beads.
Marquette, Michael J.

Targeting Helicobacter pylori with antibodies: Exploring drug delivery with polymer beads. - 98 p.

Source: Masters Abstracts International, Volume: 42-06, page: 2155.

Thesis (M.S.)--West Chester University of Pennsylvania, 2004.

The association between Helicobacter pylori (H. pylori) and gastric disease---gastritis, ulceration and carcinoma---has been recognized for some time. Because the gastrointestinal tract may be viewed as extracorporeal, a method to target delivery of an active antibiotic agent could represent a significant advance in H. pylori eradication and disease treatment. The goal of this study was to develop a model system that would allow for the specific targeting of H. pylori through the use of antibody-conjugated polymer beads. The ability of such beads to interact with H. pylori was tested by creating a macromolecular, whole-cell ELISA system. Results were assayed using alkaline phosphatase-conjugated secondary antibody and p-nitrophenyl phosphate as a developing substrate. In addition, a solution phase assay, employing acridine-orange stained H. pylori cells was utilized to examine cell-bead interactions. Results demonstrate that polymer beads conjugated with Rabbit-anti-Helicobacter pylori polyclonal antibodies specifically interact with H. pylori. Conversely, polymer beads conjugated with non-specific Rabbit IgG show a significantly reduced interaction (Student t-test p < 0.05).

ISBN: 0496254197Subjects--Topical Terms:

1017716
Health Sciences, Immunology.

Targeting Helicobacter pylori with antibodies: Exploring drug delivery with polymer beads.
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