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The effect of retinoic acid on dendr...

Hengesbach, Lindsy M.

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The effect of retinoic acid on dendritic cell development and maturation.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	The effect of retinoic acid on dendritic cell development and maturation./
作者:	Hengesbach, Lindsy M.
面頁冊數:	101 p.
附註:	Source: Masters Abstracts International, Volume: 42-06, page: 2154.
Contained By:	Masters Abstracts International42-06.
標題:	Health Sciences, Immunology. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1419962
ISBN:	049624714X

The effect of retinoic acid on dendritic cell development and maturation.
Hengesbach, Lindsy M.

The effect of retinoic acid on dendritic cell development and maturation. - 101 p.

Source: Masters Abstracts International, Volume: 42-06, page: 2154.

Thesis (M.S.)--Michigan State University, 2004.

Retinoids encompass a group of natural and synthetic molecules with structural similarities to retinol---the major form of vitamin A. Vitamin A acts through the interaction of retinoid receptors with retinoic acid response elements promoting cellular differentiation or as a prosthetic group in vision. Hence, vitamin A is essential for several biological processes including proper immune function. During vitamin A deficiency, there is a shift in the balance of T helper 1 (Th1)-cell mediated immune responses and T helper 2 (Th2)-humoral immune responses that limits T-dependent antibody responses due to inadequate Th2 cell development.

ISBN: 049624714XSubjects--Topical Terms:

1017716
Health Sciences, Immunology.

The effect of retinoic acid on dendritic cell development and maturation.
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245 1 4 $a The effect of retinoic acid on dendritic cell development and maturation.
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500 $a Source: Masters Abstracts International, Volume: 42-06, page: 2154.
500 $a Adviser: Kathleen A. Hoag.
502 $a Thesis (M.S.)--Michigan State University, 2004.
520 $a Retinoids encompass a group of natural and synthetic molecules with structural similarities to retinol---the major form of vitamin A. Vitamin A acts through the interaction of retinoid receptors with retinoic acid response elements promoting cellular differentiation or as a prosthetic group in vision. Hence, vitamin A is essential for several biological processes including proper immune function. During vitamin A deficiency, there is a shift in the balance of T helper 1 (Th1)-cell mediated immune responses and T helper 2 (Th2)-humoral immune responses that limits T-dependent antibody responses due to inadequate Th2 cell development.
520 $a Dendritic cells (DC) are specialized antigen-presenting cells that are known to influence the balance of Th1 and Th2 responses. DC differentiation is a complex process that begins in the bone marrow and is coordinated and regulated by the expression of cytokines, colony-stimulating factors, receptors, and transcription factors. Nutritional factors may play an important role in this process. Vitamin A is essential for proper immune function and has been implicated in the development of myeloid lineage cells. The objective of this research is to determine if vitamin A is critical to the proper development of immature myeloid DCs and dendritic cell maturation in a manner that may affect the resulting immune response.
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