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Micropatterning stretched and aligne...

Petit, Cecilia Anna Paulette.

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Micropatterning stretched and aligned DNA for sequence-specific nanolithography.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Micropatterning stretched and aligned DNA for sequence-specific nanolithography./
作者:	Petit, Cecilia Anna Paulette.
面頁冊數:	223 p.
附註:	Source: Dissertation Abstracts International, Volume: 66-01, Section: B, page: 0412.
Contained By:	Dissertation Abstracts International66-01B.
標題:	Engineering, Chemical. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3162770
ISBN:	0496965220

Micropatterning stretched and aligned DNA for sequence-specific nanolithography.
Petit, Cecilia Anna Paulette.

Micropatterning stretched and aligned DNA for sequence-specific nanolithography. - 223 p.

Source: Dissertation Abstracts International, Volume: 66-01, Section: B, page: 0412.

Thesis (Ph.D.)--Princeton University, 2005.

Techniques for fabricating nanostructured materials can be categorized as either "top-down" or "bottom-up". Top-down techniques use lithography and contact printing to create patterned surfaces and microfluidic channels that can corral and organize nanoscale structures, such as molecules and nanorods in contrast; bottom-up techniques use self-assembly or molecular recognition to direct the organization of materials. A central goal in nanotechnology is the integration of bottom-up and top-down assembly strategies for materials development, device design; and process integration. With this goal in mind, we have developed strategies that will allow this integration by using DNA as a template for nanofabrication; two top-down approaches allow the placement of these templates, while the bottom-up technique uses the specific sequence of bases to pattern materials along each strand of DNA.

ISBN: 0496965220Subjects--Topical Terms:

1018531
Engineering, Chemical.

Micropatterning stretched and aligned DNA for sequence-specific nanolithography.
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245 1 0 $a Micropatterning stretched and aligned DNA for sequence-specific nanolithography.
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500 $a Adviser: Jeffrey D. Carbeck.
502 $a Thesis (Ph.D.)--Princeton University, 2005.
520 $a Techniques for fabricating nanostructured materials can be categorized as either "top-down" or "bottom-up". Top-down techniques use lithography and contact printing to create patterned surfaces and microfluidic channels that can corral and organize nanoscale structures, such as molecules and nanorods in contrast; bottom-up techniques use self-assembly or molecular recognition to direct the organization of materials. A central goal in nanotechnology is the integration of bottom-up and top-down assembly strategies for materials development, device design; and process integration. With this goal in mind, we have developed strategies that will allow this integration by using DNA as a template for nanofabrication; two top-down approaches allow the placement of these templates, while the bottom-up technique uses the specific sequence of bases to pattern materials along each strand of DNA.
520 $a Our first top-down approach, termed combing of molecules in microchannels (COMMIC), produces microscopic patterns of stretched and aligned molecules of DNA on surfaces. This process consists of passing an air-water interface over end adsorbed molecules inside microfabricated channels. The geometry of the microchannel directs the placement of the DNA molecules, while the geometry of the airwater interface directs the local orientation and curvature of the molecules.
520 $a We developed another top-down strategy for creating micropatterns of stretched and aligned DNA using surface chemistry. Because DNA stretching occurs on hydrophobic surfaces, this technique uses photolithography to pattern vinyl-terminated silanes on glass When these surface-, are immersed in DNA solution, molecules adhere preferentially to the silanized areas. This approach has also proven useful in patterning protein for cell adhesion studies.
520 $a Finally, we describe the use of these stretched and aligned molecules of DNA as templates for the subsequent bottom-up construction of hetero-structures through hybridization-mediated sequence-specific nanolithography. In this process, particles are assembled via molecular recognition with functionalized probes previously hybridized to the stretched DNA template. We have used this approach to pattern proteins, metal colloids, and semiconductor quantum dots. We also demonstrate the co-assembly of two types of particles---metals and semiconductors---on single strands of DNA via the sequence-specific hybridization of two types of functional probes.
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