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Statistical mechanics of cell-cell r...

Hori, Yuko.

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Statistical mechanics of cell-cell recognition in the immune system.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Statistical mechanics of cell-cell recognition in the immune system./
作者:	Hori, Yuko.
面頁冊數:	127 p.
附註:	Source: Dissertation Abstracts International, Volume: 65-02, Section: B, page: 0758.
Contained By:	Dissertation Abstracts International65-02B.
標題:	Chemistry, Physical. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3121522
ISBN:	0496688731

Statistical mechanics of cell-cell recognition in the immune system.
Hori, Yuko.

Statistical mechanics of cell-cell recognition in the immune system. - 127 p.

Source: Dissertation Abstracts International, Volume: 65-02, Section: B, page: 0758.

Thesis (Ph.D.)--University of California, Berkeley, 2003.

Cell-cell recognition is a key event that determines the activation of T lymphocytes, which are the orchestrator of the adaptive immune system. The immunological synapse, a macroscopic spatial pattern of receptors and ligands which forms in the intercellular junction between T lymphocytes and antigen presenting cells (APCs), is implicated in information transfer between these immune cells. Based on a statistical mechanical model developed by Qi et al. (Qi, Groves et al. 2001), we will discuss the mechanisms that underlie the formation of different synapse patterns at different stages of the life cycle of T cells. The functional consequences of synapse formation to T cell activation are explored. We also develop a numerical simulation method to study intracellular signaling cascades which is coupled to synapse formation. Appling this algorithm, we seek possible explanations for some controversies regarding T cell signaling and activation.

ISBN: 0496688731Subjects--Topical Terms:

560527
Chemistry, Physical.

Statistical mechanics of cell-cell recognition in the immune system.
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