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A dynamical systems approach to esti...

Meloney, Kathleen Ann.

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A dynamical systems approach to estimating the sequences of repeat regions in the genome.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	A dynamical systems approach to estimating the sequences of repeat regions in the genome./
作者:	Meloney, Kathleen Ann.
面頁冊數:	44 p.
附註:	Source: Masters Abstracts International, Volume: 42-06, page: 2215.
Contained By:	Masters Abstracts International42-06.
標題:	Mathematics. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1419448
ISBN:	0496242180

A dynamical systems approach to estimating the sequences of repeat regions in the genome.
Meloney, Kathleen Ann.

A dynamical systems approach to estimating the sequences of repeat regions in the genome. - 44 p.

Source: Masters Abstracts International, Volume: 42-06, page: 2215.

Thesis (M.A.)--University of Maryland, College Park, 2004.

In 1982, Fred Sanger [9] introduced a cloning technique on which shotgun sequencing is based. Shotgun sequencing is a method for determining the sequence of bases (or letters) in the genome and since its introduction, many groups have used this technique to sequence the genomes of various organisms. The shotgun technique involves breaking the DNA into a large number of small pieces, each of whose sequence of letters is determined experimentally. Current technology limits the length of the sequenced pieces to approximately 500 letters. Then, like a puzzle, the pieces are assembled using computer algorithms to produce the complete sequence. The greatest difficulty with the shotgun technique is the presence of subsequences longer than 500 letters that occur multiple times in the genome with minor variations.

ISBN: 0496242180Subjects--Topical Terms:

515831
Mathematics.

A dynamical systems approach to estimating the sequences of repeat regions in the genome.
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245 1 2 $a A dynamical systems approach to estimating the sequences of repeat regions in the genome.
300 $a 44 p.
500 $a Source: Masters Abstracts International, Volume: 42-06, page: 2215.
500 $a Chair: James A. Yorke.
502 $a Thesis (M.A.)--University of Maryland, College Park, 2004.
520 $a In 1982, Fred Sanger [9] introduced a cloning technique on which shotgun sequencing is based. Shotgun sequencing is a method for determining the sequence of bases (or letters) in the genome and since its introduction, many groups have used this technique to sequence the genomes of various organisms. The shotgun technique involves breaking the DNA into a large number of small pieces, each of whose sequence of letters is determined experimentally. Current technology limits the length of the sequenced pieces to approximately 500 letters. Then, like a puzzle, the pieces are assembled using computer algorithms to produce the complete sequence. The greatest difficulty with the shotgun technique is the presence of subsequences longer than 500 letters that occur multiple times in the genome with minor variations.
520 $a We present a dynamical systems approach to estimating the sequence of letters of these long, highly repetitive subsequences in the genome. Our results suggest that this approach produces good representatives of the long repetitive subsequences in a genome. We also present potential applications of this method to genome assembly.
590 $a School code: 0117.
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