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Metabolism of toxic plant alkaloids ...

Duringer, Jennifer Marie.

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Metabolism of toxic plant alkaloids in livestock: Comparative studies on the hepatic metabolism of pyrrolizidine alkaloids in sheep and cattle and of ergot alkaloids in an endophyte-resistant mouse model.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Metabolism of toxic plant alkaloids in livestock: Comparative studies on the hepatic metabolism of pyrrolizidine alkaloids in sheep and cattle and of ergot alkaloids in an endophyte-resistant mouse model./
Author:	Duringer, Jennifer Marie.
Description:	195 p.
Notes:	Source: Dissertation Abstracts International, Volume: 64-07, Section: B, page: 3235.
Contained By:	Dissertation Abstracts International64-07B.
Subject:	Health Sciences, Toxicology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3098419
ISBN:	0496460315

Metabolism of toxic plant alkaloids in livestock: Comparative studies on the hepatic metabolism of pyrrolizidine alkaloids in sheep and cattle and of ergot alkaloids in an endophyte-resistant mouse model.
Duringer, Jennifer Marie.

Metabolism of toxic plant alkaloids in livestock: Comparative studies on the hepatic metabolism of pyrrolizidine alkaloids in sheep and cattle and of ergot alkaloids in an endophyte-resistant mouse model. - 195 p.

Source: Dissertation Abstracts International, Volume: 64-07, Section: B, page: 3235.

Thesis (Ph.D.)--Oregon State University, 2003.

The pyrrolizidine alkaloids (PAs) and ergot alkaloids are known natural toxicants found in livestock forage. These alkaloids contribute to large economic losses in livestock throughout the world. An understanding of the mechanisms of toxicity and development of better diagnostic tools for better management practices was investigated.

ISBN: 0496460315Subjects--Topical Terms:

1017752
Health Sciences, Toxicology.

Metabolism of toxic plant alkaloids in livestock: Comparative studies on the hepatic metabolism of pyrrolizidine alkaloids in sheep and cattle and of ergot alkaloids in an endophyte-resistant mouse model.
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100 1 $a Duringer, Jennifer Marie. $3 1933749
245 1 0 $a Metabolism of toxic plant alkaloids in livestock: Comparative studies on the hepatic metabolism of pyrrolizidine alkaloids in sheep and cattle and of ergot alkaloids in an endophyte-resistant mouse model.
300 $a 195 p.
500 $a Source: Dissertation Abstracts International, Volume: 64-07, Section: B, page: 3235.
500 $a Adviser: A. Morrie Craig.
502 $a Thesis (Ph.D.)--Oregon State University, 2003.
520 $a The pyrrolizidine alkaloids (PAs) and ergot alkaloids are known natural toxicants found in livestock forage. These alkaloids contribute to large economic losses in livestock throughout the world. An understanding of the mechanisms of toxicity and development of better diagnostic tools for better management practices was investigated.
520 $a Variability exists in the toxicity of PAs in ruminants where cattle are more susceptible and sheep are more resistant. The mechanism of PA resistance in sheep has been attributed to hepatic metabolism or rumen microbial degradation of PAs to non-toxic moieties. The hepatic metabolism of the PA senecionine was investigated in cattle and sheep liver microsomes. The level of a toxic pyrrole metabolite 6,7-dihydro-7-hydroxy-1-hydroxymethyl-5H-pyrrolizine pyrrole (DHP) formed in cattle and sheep were similar. However, the level of a non-toxic N-oxide metabolite was greater in sheep than in cattle. Cytochrome P450 and flavin monooxygenases (FMOs) responsible for PA oxidative metabolism were similar in both ruminant species. Therefore, hepatic metabolism of PAs is not solely responsible for resistance observed in sheep versus cattle.
520 $a Ergot alkaloids present in endophyte-infected plants also cause toxicity in livestock. HPLC is the typical method used to quantify ergot alkaloid content; however, it is costly and time-consuming. An enzyme-linked immunosorbent assay (ELISA) developed with lysergol as the hapten was evaluated to ascertain its feasibility as an analytical tool for the ergot alkaloids found in forage plants. The ELISA detected the presence of lysergic acid but was not a reliable assay for the ergopeptine alkaloids such as ergovaline.
520 $a The genetic divergence in mice previously selected into ergot alkaloid susceptible and resistant lines was studied after ten generations of relaxed selection. Physiologically no difference was seen between the susceptible and resistant line for average daily weight gain. However, hepatic metabolism of the ergot alkaloid ergotamine showed differences between genders and between animals on diets containing no ergot alkaloids or a high concentration of ergot alkaloids. Four major biotransformation products were identified as hydroxylated ergotamine isomers based on mass spectroscopic analysis.
590 $a School code: 0172.
650 4 $a Health Sciences, Toxicology. $3 1017752
650 4 $a Biology, Veterinary Science. $3 1021733
690 $a 0383
690 $a 0778
710 2 0 $a Oregon State University. $3 625720
773 0 $t Dissertation Abstracts International $g 64-07B.
790 1 0 $a Craig, A. Morrie, $e advisor
790 $a 0172
791 $a Ph.D.
792 $a 2003
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3098419