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DNA Display: In vitro evolution of ...

Halpin, David Riggs.

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DNA Display: In vitro evolution of combinatorial chemistry libraries.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	DNA Display: In vitro evolution of combinatorial chemistry libraries./
作者:	Halpin, David Riggs.
面頁冊數:	122 p.
附註:	Source: Dissertation Abstracts International, Volume: 65-04, Section: B, page: 1689.
Contained By:	Dissertation Abstracts International65-04B.
標題:	Biology, Molecular. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3128397
ISBN:	0496756591

DNA Display: In vitro evolution of combinatorial chemistry libraries.
Halpin, David Riggs.

DNA Display: In vitro evolution of combinatorial chemistry libraries. - 122 p.

Source: Dissertation Abstracts International, Volume: 65-04, Section: B, page: 1689.

Thesis (Ph.D.)--Stanford University, 2004.

Man has used evolution as a tool for centuries, the earliest example being the breeding of crops and animals. Within the past 15 years, techniques have emerged that enable the cell-free evolution of DNA, RNA, and protein macromolecules for various functions, ranging from binding specificity to catalytic activity.

ISBN: 0496756591Subjects--Topical Terms:

1017719
Biology, Molecular.

DNA Display: In vitro evolution of combinatorial chemistry libraries.
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500 $a Adviser: Pehr Harbury.
502 $a Thesis (Ph.D.)--Stanford University, 2004.
520 $a Man has used evolution as a tool for centuries, the earliest example being the breeding of crops and animals. Within the past 15 years, techniques have emerged that enable the cell-free evolution of DNA, RNA, and protein macromolecules for various functions, ranging from binding specificity to catalytic activity.
520 $a This thesis reports the design and implementation of DNA Display, a method for the evolution of small-molecule populations produced by synthetic organic chemistry. The technique imparts an artificial genetic code upon small molecules, enabling their reproduction and breeding. DNA Display was successfully used to evolve a library of one million non-natural peptides for binding to a protein target. The process is simple and inexpensive, making small-molecule discovery widely accessible.
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