東華大學圖書館 |

語系: 繁體中文

說明(常見問題)

回圖書館首頁

手機版館藏查詢

登入

回首頁

切換: 標籤 | MARC模式 | ISBD

Guanidine-based molecular transporte...

VanDeusen, Christopher Loren.

FindBook

Google Book

Amazon

博客來

Guanidine-based molecular transporters for drug delivery.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Guanidine-based molecular transporters for drug delivery./
作者:	VanDeusen, Christopher Loren.
面頁冊數:	378 p.
附註:	Source: Dissertation Abstracts International, Volume: 64-03, Section: B, page: 1254.
Contained By:	Dissertation Abstracts International64-03B.
標題:	Chemistry, Organic. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3085236
ISBN:	0496330438

Guanidine-based molecular transporters for drug delivery.
VanDeusen, Christopher Loren.

Guanidine-based molecular transporters for drug delivery. - 378 p.

Source: Dissertation Abstracts International, Volume: 64-03, Section: B, page: 1254.

Thesis (Ph.D.)--Stanford University, 2003.

One way to solve problems with drugs that have formulation issues along with poor penetration of biological barriers is to couple them to molecules that do not rely on passive diffusion to move into cells and tissues. It has recently been discovered that certain classes of polar peptides efficiently penetrate through the cell membranes. Furthermore, it has been shown that these peptides, when conjugated to therapeutics, enable the penetration of the therapeutics through membranes that would otherwise limit uptake. In particular, the highly basic domain of the HIV-1 TAT protein has been shown to rapidly enter cells in an energy dependent fashion through a mechanism that is to date poorly understood. Researchers at the Stanford Medical Center discovered that the highly basic arginine residues appear to be responsible for the ability of the short oligopeptide to cross the cell membrane. Furthermore, it has been demonstrated that short homooligomers of arginine cross the cell membrane much more rapidly than the parent TAT sequence. This thesis outlines some of our work to apply this discovery to the delivery of potent therapeutics into a biological setting.

ISBN: 0496330438Subjects--Topical Terms:

516206
Chemistry, Organic.

Guanidine-based molecular transporters for drug delivery.
LDR:02032nmm 2200277 4500 001 1843685
005 20051017073350.5
008 130614s2003 eng d
020 $a 0496330438
035 $a (UnM)AAI3085236
035 $a AAI3085236
040 $a UnM $c UnM
100 1 $a VanDeusen, Christopher Loren. $3 1931906
245 1 0 $a Guanidine-based molecular transporters for drug delivery.
300 $a 378 p.
500 $a Source: Dissertation Abstracts International, Volume: 64-03, Section: B, page: 1254.
500 $a Adviser: Paul A. Wender.
502 $a Thesis (Ph.D.)--Stanford University, 2003.
520 $a One way to solve problems with drugs that have formulation issues along with poor penetration of biological barriers is to couple them to molecules that do not rely on passive diffusion to move into cells and tissues. It has recently been discovered that certain classes of polar peptides efficiently penetrate through the cell membranes. Furthermore, it has been shown that these peptides, when conjugated to therapeutics, enable the penetration of the therapeutics through membranes that would otherwise limit uptake. In particular, the highly basic domain of the HIV-1 TAT protein has been shown to rapidly enter cells in an energy dependent fashion through a mechanism that is to date poorly understood. Researchers at the Stanford Medical Center discovered that the highly basic arginine residues appear to be responsible for the ability of the short oligopeptide to cross the cell membrane. Furthermore, it has been demonstrated that short homooligomers of arginine cross the cell membrane much more rapidly than the parent TAT sequence. This thesis outlines some of our work to apply this discovery to the delivery of potent therapeutics into a biological setting.
590 $a School code: 0212.
650 4 $a Chemistry, Organic. $3 516206
650 4 $a Health Sciences, Pharmacy. $3 1017737
690 $a 0490
690 $a 0572
710 2 0 $a Stanford University. $3 754827
773 0 $t Dissertation Abstracts International $g 64-03B.
790 1 0 $a Wender, Paul A., $e advisor
790 $a 0212
791 $a Ph.D.
792 $a 2003
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3085236