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Alterations in the permeability of c...

Taur, Jan-Shiang.

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Alterations in the permeability of cimetidine by dietary flavonoids using an in vitro transport model, Caco-2 cells.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Alterations in the permeability of cimetidine by dietary flavonoids using an in vitro transport model, Caco-2 cells./
作者:	Taur, Jan-Shiang.
面頁冊數:	146 p.
附註:	Source: Dissertation Abstracts International, Volume: 64-08, Section: B, page: 3768.
Contained By:	Dissertation Abstracts International64-08B.
標題:	Health Sciences, Pharmacy. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3103576
ISBN:	0496511441

Alterations in the permeability of cimetidine by dietary flavonoids using an in vitro transport model, Caco-2 cells.
Taur, Jan-Shiang.

Alterations in the permeability of cimetidine by dietary flavonoids using an in vitro transport model, Caco-2 cells. - 146 p.

Source: Dissertation Abstracts International, Volume: 64-08, Section: B, page: 3768.

Thesis (Ph.D.)--Oregon State University, 2003.

The goal of this dissertation is to investigate the interaction between cimetidine and dietary flavonoids using the Caco-2 cell transport model. It has been shown that flavonoids can change the bioavailability of pharmaceuticals, either by inhib

ISBN: 0496511441Subjects--Topical Terms:

1017737
Health Sciences, Pharmacy.

Alterations in the permeability of cimetidine by dietary flavonoids using an in vitro transport model, Caco-2 cells.
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245 1 0 $a Alterations in the permeability of cimetidine by dietary flavonoids using an in vitro transport model, Caco-2 cells.
300 $a 146 p.
500 $a Source: Dissertation Abstracts International, Volume: 64-08, Section: B, page: 3768.
500 $a Adviser: Rosita J. Rodriguez.
502 $a Thesis (Ph.D.)--Oregon State University, 2003.
520 $a The goal of this dissertation is to investigate the interaction between cimetidine and dietary flavonoids using the Caco-2 cell transport model. It has been shown that flavonoids can change the bioavailability of pharmaceuticals, either by inhib
520 $a The second objective was to describe the transport characteristics of cimetidine in the Caco-2 cell monolayers. The permeability of cimetidine was determined at different pH environments. When the permeability of cimetidine from apical to basola
520 $a The third objective was to study the effect of dietary flavonoids on the permeability of cimetidine in the Caco-2 cell model. In the present study, four different flavonoids, quercetin, genistein, naringenin, and xanthohumol were selected. When
520 $a The present studies demonstrate that some dietary flavonoids, especially aglycones, can significantly reduce the efflux of cimetidine in the Caco-2 cell monolayers. Therefore, the flavonoids consumed in a normal diet have the potential to enhanc
590 $a School code: 0172.
650 4 $a Health Sciences, Pharmacy. $3 1017737
650 4 $a Biology, Cell. $3 1017686
650 4 $a Health Sciences, Pharmacology. $3 1017717
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